A0AAA9TQU1 · A0AAA9TQU1_BOVIN

  • Protein
    Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase
  • Gene
    PPIP5K2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).

Catalytic activity

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functiondiphosphoinositol-pentakisphosphate kinase activity
Molecular Functioninositol heptakisphosphate kinase activity
Molecular Functioninositol hexakisphosphate kinase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase
  • EC number

Gene names

    • Name
      PPIP5K2

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Hereford
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    A0AAA9TQU1

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain6-66VIP1 N-terminal
Region837-873Disordered
Compositional bias849-873Basic and acidic residues
Region967-1057Disordered
Compositional bias968-1003Polar residues
Compositional bias1010-1039Polar residues

Sequence similarities

Belongs to the histidine acid phosphatase family. VIP1 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,057
  • Mass (Da)
    119,920
  • Last updated
    2024-05-29 v1
  • Checksum
    0FA7430D0B099599
MNTCQLTVITRSSDCISRNKLQQTHVSVSIERMLFSGFPLDKAVAYAKLRNPFVINDLNMQYLIQDRREVYSILQAEGILLPRYAILNRDPNNPKECNLIEGEDHVEVNGEVFQKPFVEKPVSAEDHNVYIYYPTSAGGGSQRLFRKIGSRSSVYSPESNVRKTGSYIYEEFMPTDGTDVKVYTVGPDYAHAEARKSPALDGKVERDSEGKEVRYPVILNAREKLIAWKVCLAFKQTVCGFDLLRANGQSYVCDVNGFSFVKNSMKYYDDCAKILGNIVMRELAPQFHIPWSIPLEAEDIPIVPTTSGTMMELRCVIAVIRHGDRTPKQKMKMEVRHQKFFDLFEKCDGYKSGKLKLKKPKQLQAMLDIARQLLMELGQNNDSEIEENKSKLEQLKTVLEMYGHFSGINRKVQLTYLPHGCPKTSSEEEDSRREEPSLLLVLKWGGELTPAGRVQAEELGRAFRCMYPGGQGDYAGFPGCGLLRLHSTYRHDLKIYASDEGRVQMTAAAFAKGLLALEGELTPILVQMVKSANMNGLLDSDSDSLSSCQQRVKARLHEILQRDRDFTAEDYEKLTPSGSISLIKSMHLIKNPVKTCDTVYSLIQSLTSQIRHRMEDPKSSDIQLYHSETLELMLRRWSKLEKDFKTKNGRYDISKIPDIYDCIKYDVQHNGSLKLEDTMELYRLSKALADIVIPQEYGITKAEKLEIAKGYCTPLVRKIRSDLQRTQDDDTVNKLHPVYSRGVLSPERHVRTRLYFTSESHVHSLLSILRYGALCDESKDEQWKRAMDYLNVVNELNYMTQIVIMLYEDPNKDLSSEERFHVELHFSPGAKGCEEDKNLPSGYGYRPASRENEGRRAFKIDSDDEPHTSKKDEVDRAVILFKPMVSEPIHIHRKSPLPRSRKMATNEVVSENANYLRTPRTLVEQKQNPTVGFELYSMVPSICPLETLHNALSLKQVDEFLASIASPSSEVPRKTPETSSLTSRSSPIMRRKVSLNTYTPAKILPTPPASIKSTKASSKPAPSGPSNTAVPNTSSRKKGVTSKTEMHEHKKNTSKKK

Computationally mapped potential isoform sequences

There are 7 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A3Q1M2A3A0A3Q1M2A3_BOVINPPIP5K21286
A0A3Q1LKY2A0A3Q1LKY2_BOVINPPIP5K21088
A0A3Q1N5J8A0A3Q1N5J8_BOVINPPIP5K21194
A0A3Q1N807A0A3Q1N807_BOVINPPIP5K21027
F1MNG6F1MNG6_BOVINPPIP5K21231
A0A3Q1M0A9A0A3Q1M0A9_BOVINPPIP5K21249
A0A3Q1M5G6A0A3Q1M5G6_BOVINPPIP5K21188

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias849-873Basic and acidic residues
Compositional bias968-1003Polar residues
Compositional bias1010-1039Polar residues

Keywords

Genome annotation databases

Similar Proteins

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