A0AAA9TGJ2 · A0AAA9TGJ2_BOVIN

  • Protein
    Histone deacetylase
  • Gene
    HDAC7
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

Catalytic activity

Features

Showing features for binding site, active site, site.

1958100200300400500600700800900
Type
IDPosition(s)Description
Binding site539Zn2+ (UniProtKB | ChEBI)
Binding site541Zn2+ (UniProtKB | ChEBI)
Binding site547Zn2+ (UniProtKB | ChEBI)
Binding site624Zn2+ (UniProtKB | ChEBI)
Active site676
Site849Contributes to catalysis

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular Functionhistone deacetylase activity
Molecular Functionmetal ion binding
Biological Processnegative regulation of transcription by RNA polymerase II

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Histone deacetylase
  • EC number

Gene names

    • Name
      HDAC7

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Hereford
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    A0AAA9TGJ2

Proteomes

Organism-specific databases

Subcellular Location

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region9-58Disordered
Compositional bias23-39Pro residues
Region187-290Disordered
Compositional bias237-261Polar residues
Region349-379Disordered
Compositional bias393-412Basic and acidic residues
Region393-446Disordered
Compositional bias425-439Basic and acidic residues
Region474-518Disordered
Compositional bias486-518Polar residues
Domain547-865Histone deacetylase

Sequence similarities

Belongs to the histone deacetylase family. HD type 2 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    958
  • Mass (Da)
    103,698
  • Last updated
    2024-05-29 v1
  • Checksum
    97626F6B0C6950E0
MRCLCQRAAADGTQVSPAAPCSSPPIIGWPRPRADTPGPQPQPMDLRVGQRPPVEPPPEPTLLALQHPQRLHHHLFLAGLQPQRSAEPMRLSMDTPMPELQMGQQEQELRQLLNKDKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPNSPSVPYRTLEPLETEGAARSMLSSFLPPVPSLPCDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHGPNPVLGSEADGDRRTHATLGPRGPVLGNPHAHLFLPHGLEPEAGGPLPSRLQPILLLDPSVTHTPLLTVPGLGPLPFHFAQSLLTTERPSGSGLHRPLSRTRSEPLPPSATTPSLLGPLQPRLERLKPHVQLIKRSAKPSEKPRLRQIPSAEDLETDGGSVGPLRDDGLEHRESSHGQQEARGTVPLQQHQQVFLWEQQRLAGRLPRGATGDSVLLPLAPGSHRPLSRAQSSPAAPASLSTPEPASQARILPSSETPARTLPFTTGLVYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLLERGLRSQCESLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQGKASKILIVDWDVHHGNGTQQTFYQDPNVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPPPLGGYHVSAKCFGYMTQQLMSLAGGAVVLALEGGHDLTAICDASEACVAALLGNKVDPLSEEGWKQKPNLNAIRSLEAVIRVHSEYWGCMQRLASRPDSWVHRVPGADAEEVEAVTALASLSVGILAEERTSGQLVEEEEPMNL

Computationally mapped potential isoform sequences

There are 9 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A3Q1N0A4A0A3Q1N0A4_BOVINHDAC71036
A0A3Q1NGD6A0A3Q1NGD6_BOVINHDAC7988
A0AAA9T6A2A0AAA9T6A2_BOVINHDAC7986
A0A3Q1MXW3A0A3Q1MXW3_BOVINHDAC7970
F1N616F1N616_BOVINHDAC7988
A0A3Q1MDL2A0A3Q1MDL2_BOVINHDAC7969
A0A3Q1MDB6A0A3Q1MDB6_BOVINHDAC7995
A0AAA9U2N9A0AAA9U2N9_BOVINHDAC7999
A0A3Q1MPP6A0A3Q1MPP6_BOVINHDAC7972

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias23-39Pro residues
Compositional bias237-261Polar residues
Compositional bias393-412Basic and acidic residues
Compositional bias425-439Basic and acidic residues
Compositional bias486-518Polar residues

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp