A0AAA9T971 · A0AAA9T971_BOVIN
- ProteinMyotubularin
- GeneMTM1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids618 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not for myogenesis. In skeletal muscles, stabilizes MTMR12 protein levels.
Catalytic activity
- 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate
- 1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-3-phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate
- 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 328-329 | substrate | ||||
Sequence: NI | ||||||
Active site | 390 | Phosphocysteine intermediate | ||||
Sequence: C | ||||||
Binding site | 390-396 | substrate | ||||
Sequence: CSDGWDR |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | filopodium | |
Cellular Component | late endosome | |
Cellular Component | plasma membrane | |
Cellular Component | ruffle | |
Cellular Component | sarcomere | |
Molecular Function | phosphoprotein phosphatase activity | |
Biological Process | dephosphorylation | |
Biological Process | lipid metabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMyotubularin
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos
Accessions
- Primary accessionA0AAA9T971
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Keywords
- Cellular component
Interaction
Subunit
Heterodimer with MTMR12. Interacts with KMT2A/MLL1 (via SET domain). Interacts with DES in skeletal muscle but not in cardiac muscle. Interacts with SPEG.
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-32 | Disordered | ||||
Sequence: MASAPTSKYNSHSLENESIKRTSRDGVNRDVG | ||||||
Compositional bias | 14-31 | Basic and acidic residues | ||||
Sequence: LENESIKRTSRDGVNRDV | ||||||
Domain | 178-553 | Myotubularin phosphatase | ||||
Sequence: GWTVYNPVEEYRRQGLPNHHWRITFINKCYKLCDTYPALLVVPYRASDEDLRRVATFRSRNRIPVLSWIHPENKTVIVRCSQPLVGMSGKRNKEDERYLDVIRETNRQVNKLTIYDARPNVNAVANKATGGGYESDDVYHNAELFFLDIHNIHVMRESLKKVKDIVYPNVEESHWLSSLESTHWLEHIKLVLTGAIQVADRVSSGKSSVVVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEILVQKEWISFGHKFASRIGHGDKNHADADRSPIFLQFIDCVWQMSKQFPTAFEFNERFLITILDHLYSCRFGTFLYNCESAREKQKVTERTVSLWSLINSNKDKFKNPFYTKEINRVLYPVASMRHLELWVNYY | ||||||
Domain | 359-421 | Tyrosine specific protein phosphatases | ||||
Sequence: THWLEHIKLVLTGAIQVADRVSSGKSSVVVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEIL | ||||||
Region | 595-618 | Disordered | ||||
Sequence: AKLSDPSASPSSPSQMMPHVQTHF |
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length618
- Mass (Da)71,647
- Last updated2024-05-29 v1
- Checksum8446D8AEF90E3B93
Computationally mapped potential isoform sequences
There are 9 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A6QLT4 | MTM1_BOVIN | MTM1 | 603 | ||
A0AAA9SKR1 | A0AAA9SKR1_BOVIN | MTM1 | 540 | ||
A0AAA9T6G6 | A0AAA9T6G6_BOVIN | MTM1 | 572 | ||
A0AAA9T4H2 | A0AAA9T4H2_BOVIN | MTM1 | 547 | ||
A0AAA9TFD2 | A0AAA9TFD2_BOVIN | MTM1 | 149 | ||
A0AAA9TYV2 | A0AAA9TYV2_BOVIN | MTM1 | 532 | ||
A0AAA9S4X8 | A0AAA9S4X8_BOVIN | MTM1 | 556 | ||
A0A3Q1M460 | A0A3Q1M460_BOVIN | MTM1 | 544 | ||
A0AAF6YZK0 | A0AAF6YZK0_BOVIN | MTM1 | 406 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 14-31 | Basic and acidic residues | ||||
Sequence: LENESIKRTSRDGVNRDV |
Keywords
- Technical term