A0AAA9T971 · A0AAA9T971_BOVIN

  • Protein
    Myotubularin
  • Gene
    MTM1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not for myogenesis. In skeletal muscles, stabilizes MTMR12 protein levels.

Catalytic activity

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site328-329substrate
Active site390Phosphocysteine intermediate
Binding site390-396substrate

GO annotations

AspectTerm
Cellular Componentfilopodium
Cellular Componentlate endosome
Cellular Componentplasma membrane
Cellular Componentruffle
Cellular Componentsarcomere
Molecular Functionphosphoprotein phosphatase activity
Biological Processdephosphorylation
Biological Processlipid metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Myotubularin
  • EC number
  • Alternative names
    • Phosphatidylinositol-3,5-bisphosphate 3-phosphatase
    • Phosphatidylinositol-3-phosphate phosphatase

Gene names

    • Name
      MTM1

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Hereford
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    A0AAA9T971

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Peripheral membrane protein
Cell projection, filopodium
Cell projection, ruffle
Cytoplasm, myofibril, sarcomere
Late endosome

Keywords

Interaction

Subunit

Heterodimer with MTMR12. Interacts with KMT2A/MLL1 (via SET domain). Interacts with DES in skeletal muscle but not in cardiac muscle. Interacts with SPEG.

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1-32Disordered
Compositional bias14-31Basic and acidic residues
Domain178-553Myotubularin phosphatase
Domain359-421Tyrosine specific protein phosphatases
Region595-618Disordered

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    618
  • Mass (Da)
    71,647
  • Last updated
    2024-05-29 v1
  • Checksum
    8446D8AEF90E3B93
MASAPTSKYNSHSLENESIKRTSRDGVNRDVGETLPRLPGEIRITDKEVIYICPFNGPIKGRVYITNYRLYLRSLETPSCPWPLEADTCVVQDSALILDVPLGVISRIEKMGGATSRGENSYGLDITCKDLRNLRFALKQEGHSRRDMFEILTRYAFPLAHSLPIFAFLNEEKFNVDGWTVYNPVEEYRRQGLPNHHWRITFINKCYKLCDTYPALLVVPYRASDEDLRRVATFRSRNRIPVLSWIHPENKTVIVRCSQPLVGMSGKRNKEDERYLDVIRETNRQVNKLTIYDARPNVNAVANKATGGGYESDDVYHNAELFFLDIHNIHVMRESLKKVKDIVYPNVEESHWLSSLESTHWLEHIKLVLTGAIQVADRVSSGKSSVVVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEILVQKEWISFGHKFASRIGHGDKNHADADRSPIFLQFIDCVWQMSKQFPTAFEFNERFLITILDHLYSCRFGTFLYNCESAREKQKVTERTVSLWSLINSNKDKFKNPFYTKEINRVLYPVASMRHLELWVNYYIRWNPRIKQQQPNPVEQRYMELLALRDEYIKRLDELQLANSAKLSDPSASPSSPSQMMPHVQTHF

Computationally mapped potential isoform sequences

There are 9 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A6QLT4MTM1_BOVINMTM1603
A0AAA9SKR1A0AAA9SKR1_BOVINMTM1540
A0AAA9T6G6A0AAA9T6G6_BOVINMTM1572
A0AAA9T4H2A0AAA9T4H2_BOVINMTM1547
A0AAA9TFD2A0AAA9TFD2_BOVINMTM1149
A0AAA9TYV2A0AAA9TYV2_BOVINMTM1532
A0AAA9S4X8A0AAA9S4X8_BOVINMTM1556
A0A3Q1M460A0A3Q1M460_BOVINMTM1544
A0AAF6YZK0A0AAF6YZK0_BOVINMTM1406

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias14-31Basic and acidic residues

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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