A0AAA9T6A2 · A0AAA9T6A2_BOVIN
- ProteinHistone deacetylase
- GeneHDAC7
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids986 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
Catalytic activity
- N6-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate
Features
Showing features for binding site, active site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 567 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 569 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 575 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 652 | Zn2+ (UniProtKB | ChEBI) | |||
Active site | 704 | ||||
Site | 877 | Contributes to catalysis | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | histone deacetylase activity | |
Molecular Function | metal ion binding | |
Biological Process | negative regulation of transcription by RNA polymerase II |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHistone deacetylase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos
Accessions
- Primary accessionA0AAA9T6A2
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-56 | Disordered | |||
Compositional bias | 19-35 | Pro residues | |||
Region | 183-263 | Disordered | |||
Compositional bias | 233-257 | Polar residues | |||
Region | 294-313 | Disordered | |||
Region | 377-474 | Disordered | |||
Compositional bias | 416-440 | Basic and acidic residues | |||
Compositional bias | 453-467 | Basic and acidic residues | |||
Region | 502-546 | Disordered | |||
Compositional bias | 514-546 | Polar residues | |||
Domain | 575-893 | Histone deacetylase | |||
Sequence similarities
Belongs to the histone deacetylase family. HD type 2 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length986
- Mass (Da)106,555
- Last updated2024-05-29 v1
- Checksum439C30AB8A2F3691
Computationally mapped potential isoform sequences
There are 9 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A3Q1N0A4 | A0A3Q1N0A4_BOVIN | HDAC7 | 1036 | ||
A0A3Q1NGD6 | A0A3Q1NGD6_BOVIN | HDAC7 | 988 | ||
A0A3Q1MXW3 | A0A3Q1MXW3_BOVIN | HDAC7 | 970 | ||
A0AAA9TGJ2 | A0AAA9TGJ2_BOVIN | HDAC7 | 958 | ||
F1N616 | F1N616_BOVIN | HDAC7 | 988 | ||
A0A3Q1MDL2 | A0A3Q1MDL2_BOVIN | HDAC7 | 969 | ||
A0A3Q1MDB6 | A0A3Q1MDB6_BOVIN | HDAC7 | 995 | ||
A0AAA9U2N9 | A0AAA9U2N9_BOVIN | HDAC7 | 999 | ||
A0A3Q1MPP6 | A0A3Q1MPP6_BOVIN | HDAC7 | 972 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 19-35 | Pro residues | |||
Compositional bias | 233-257 | Polar residues | |||
Compositional bias | 416-440 | Basic and acidic residues | |||
Compositional bias | 453-467 | Basic and acidic residues | |||
Compositional bias | 514-546 | Polar residues | |||
Keywords
- Technical term