A0AAA9T6A2 · A0AAA9T6A2_BOVIN

  • Protein
    Histone deacetylase
  • Gene
    HDAC7
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

Catalytic activity

Features

Showing features for binding site, active site, site.

1986100200300400500600700800900
Type
IDPosition(s)Description
Binding site567Zn2+ (UniProtKB | ChEBI)
Binding site569Zn2+ (UniProtKB | ChEBI)
Binding site575Zn2+ (UniProtKB | ChEBI)
Binding site652Zn2+ (UniProtKB | ChEBI)
Active site704
Site877Contributes to catalysis

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular Functionhistone deacetylase activity
Molecular Functionmetal ion binding
Biological Processnegative regulation of transcription by RNA polymerase II

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Histone deacetylase
  • EC number

Gene names

    • Name
      HDAC7

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Hereford
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    A0AAA9T6A2

Proteomes

Organism-specific databases

Subcellular Location

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region1-56Disordered
Compositional bias19-35Pro residues
Region183-263Disordered
Compositional bias233-257Polar residues
Region294-313Disordered
Region377-474Disordered
Compositional bias416-440Basic and acidic residues
Compositional bias453-467Basic and acidic residues
Region502-546Disordered
Compositional bias514-546Polar residues
Domain575-893Histone deacetylase

Sequence similarities

Belongs to the histone deacetylase family. HD type 2 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    986
  • Mass (Da)
    106,555
  • Last updated
    2024-05-29 v1
  • Checksum
    439C30AB8A2F3691
MHSPGADGTQVSPAAPCSSPPIIGWPRPRADTPGPQPQPMDLRVGQRPPVEPPPEPTLLALQHPQRLHHHLFLAGLQPQRSAEPMRLSMDTPMPELQMGQQEQELRQLLNKDKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPNSPSVPYRTLEPLETEGAARSMLSSFLPPVPSLPCDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHGPNPVLGSEALLGQRLRLQETSLAPFALLPTITLGLPAPARADGDRRTHATLGPRGPVLGNPHAHLFLPHGLEPEAGGPLPSRLQPILLLDPSVTHTPLLTVPGLGPLPFHFAQSLLTTERPSGSGLHRPLSRTRSEPLPPSATTPSLLGPLQPRLERLKPHVQLIKRSAKPSEKPRLRQIPSAEDLETDGGSVGPLRDDGLEHRESSHGQQEARGTVPLQQHQQVFLWEQQRLAGRLPRGATGDSVLLPLAPGSHRPLSRAQSSPAAPASLSTPEPASQARILPSSETPARTLPFTTGLVYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLLERGLRSQCESLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQGKASKILIVDWDVHHGNGTQQTFYQDPNVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPPPLGGYHVSAKCFGYMTQQLMSLAGGAVVLALEGGHDLTAICDASEACVAALLGNKVDPLSEEGWKQKPNLNAIRSLEAVIRVHSEYWGCMQRLASRPDSWVHRVPGADAEEVEAVTALASLSVGILAEERTSGQLVEEEEPMNL

Computationally mapped potential isoform sequences

There are 9 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A3Q1N0A4A0A3Q1N0A4_BOVINHDAC71036
A0A3Q1NGD6A0A3Q1NGD6_BOVINHDAC7988
A0A3Q1MXW3A0A3Q1MXW3_BOVINHDAC7970
A0AAA9TGJ2A0AAA9TGJ2_BOVINHDAC7958
F1N616F1N616_BOVINHDAC7988
A0A3Q1MDL2A0A3Q1MDL2_BOVINHDAC7969
A0A3Q1MDB6A0A3Q1MDB6_BOVINHDAC7995
A0AAA9U2N9A0AAA9U2N9_BOVINHDAC7999
A0A3Q1MPP6A0A3Q1MPP6_BOVINHDAC7972

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias19-35Pro residues
Compositional bias233-257Polar residues
Compositional bias416-440Basic and acidic residues
Compositional bias453-467Basic and acidic residues
Compositional bias514-546Polar residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

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