A0AAA9T4Y7 · A0AAA9T4Y7_BOVIN

  • Protein
    Carnitine O-palmitoyltransferase 2, mitochondrial
  • Gene
    CPT2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Involved in the intramitochondrial synthesis of acylcarnitines from accumulated acyl-CoA metabolites. Reconverts acylcarnitines back into the respective acyl-CoA esters that can then undergo beta-oxidation, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Active with medium (C8-C12) and long-chain (C14-C18) acyl-CoA esters.

Catalytic activity

  • (5Z)-tetradecenoyl-CoA + (R)-carnitine = O-(5Z)-tetradecenoyl-(R)-carnitine + CoA
  • (R)-carnitine + (9Z)-octadecenoyl-CoA = O-(9Z)-octadecenoyl-(R)-carnitine + CoA
  • (9Z)-tetradecenoyl-CoA + (R)-carnitine = O-(9Z)-tetradecenoyl-(R)-carnitine + CoA
  • 4,8-dimethylnonanoyl-CoA + (R)-carnitine = O-4,8-dimethylnonanoyl-(R)-carnitine + CoA
  • decanoyl-CoA + (R)-carnitine = O-decanoyl-(R)-carnitine + CoA
  • dodecanoyl-CoA + (R)-carnitine = O-dodecanoyl-R-carnitine + CoA
  • eicosanoyl-CoA + (R)-carnitine = O-eicosanoyl-(R)-carnitine + CoA
  • (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA
    This reaction proceeds in the backward direction.
    EC:2.3.1.21 (UniProtKB | ENZYME | Rhea)
  • (R)-carnitine + octadecanoyl-CoA = O-octadecanoyl-(R)-carnitine + CoA
  • octanoyl-CoA + (R)-carnitine = O-octanoyl-(R)-carnitine + CoA
  • tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA

Pathway

Lipid metabolism; fatty acid beta-oxidation.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site332Proton acceptor

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functionacyltransferase activity
Biological Processfatty acid metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Carnitine O-palmitoyltransferase 2, mitochondrial
  • EC number
  • Alternative names
    • Carnitine palmitoyltransferase II

Gene names

    • Name
      CPT2

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Hereford
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    A0AAA9T4Y7

Proteomes

Organism-specific databases

Subcellular Location

Mitochondrion inner membrane
; Peripheral membrane protein

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain12-602Choline/carnitine acyltransferase

Sequence similarities

Belongs to the carnitine/choline acetyltransferase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    618
  • Mass (Da)
    70,164
  • Last updated
    2024-05-29 v1
  • Checksum
    950E7256E901745D
MRFLISEILERLPIPKLEDTIRRYLSAQKPLLDDSQFRKTEQLCKSFETGIGKELHEQLVTQDKQNKHTSYISGPWFDMYLTARDPVVLNFNPFISFNPDPKSEYNDQLTRATNMTVSAIRFLKTLRADLLEPEVFHLNPAKSDTDTFKRFIRFVPSFLSWYGAYLVNAYPLDMSQYYRLFNSTRLPRPHRDELFTDDKARHLLVLRKGHFYIFDVLDQDGNIVSASEIQAHLKYILSDNSPAPEFPLSYLTSENRDIWAELRQKLVSGGNEATLGKVDSAVFCLCLDDFPIRDFVHLSHSMLHGDGTNRWFDKSFNLIIAKDGTAAIHFEHAWGDGVAVLRFFNEVFKDSTQAPAITPQSQPASTDSSVAVQKLNFKLSDALKTGISAAKEKFDATVKSLTIDYIRFQRGGREFLKKQKLSPDSMAQLAFQMAFLRQYGQTVATYESCSTAAFKHGRTETIRPASIFTKTCSEAFVREPSKYSAGELQQMMAKCSTYHNQLTREAAMGQGFDRHLFALRYLAAARGISMPELFLDPAYRQINHNILSTSTLSSPAVNIGCFAPVVPDGFGIGYSVQDNWIGCNVSAYQSRNAREFLQCVEKALEDMFDALEGKMIKT

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
F1N1M7F1N1M7_BOVINCPT2658
A0AAA9TSV1A0AAA9TSV1_BOVINCPT2620
A0AAA9S9B1A0AAA9S9B1_BOVINCPT2223

Keywords

Genome annotation databases

Similar Proteins

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