A0AAA9T4Y7 · A0AAA9T4Y7_BOVIN
- ProteinCarnitine O-palmitoyltransferase 2, mitochondrial
- GeneCPT2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids618 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Involved in the intramitochondrial synthesis of acylcarnitines from accumulated acyl-CoA metabolites. Reconverts acylcarnitines back into the respective acyl-CoA esters that can then undergo beta-oxidation, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Active with medium (C8-C12) and long-chain (C14-C18) acyl-CoA esters.
Catalytic activity
- (5Z)-tetradecenoyl-CoA + (R)-carnitine = O-(5Z)-tetradecenoyl-(R)-carnitine + CoA
- (R)-carnitine + (9Z)-octadecenoyl-CoA = O-(9Z)-octadecenoyl-(R)-carnitine + CoA
- (9Z)-tetradecenoyl-CoA + (R)-carnitine = O-(9Z)-tetradecenoyl-(R)-carnitine + CoA
- 4,8-dimethylnonanoyl-CoA + (R)-carnitine = O-4,8-dimethylnonanoyl-(R)-carnitine + CoA
- decanoyl-CoA + (R)-carnitine = O-decanoyl-(R)-carnitine + CoA
- dodecanoyl-CoA + (R)-carnitine = O-dodecanoyl-R-carnitine + CoA
- eicosanoyl-CoA + (R)-carnitine = O-eicosanoyl-(R)-carnitine + CoA
- (R)-carnitine + octadecanoyl-CoA = O-octadecanoyl-(R)-carnitine + CoA
- octanoyl-CoA + (R)-carnitine = O-octanoyl-(R)-carnitine + CoA
- tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
Pathway
Lipid metabolism; fatty acid beta-oxidation.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 332 | Proton acceptor | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Molecular Function | acyltransferase activity | |
Biological Process | fatty acid metabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCarnitine O-palmitoyltransferase 2, mitochondrial
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos
Accessions
- Primary accessionA0AAA9T4Y7
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 12-602 | Choline/carnitine acyltransferase | ||||
Sequence: LPIPKLEDTIRRYLSAQKPLLDDSQFRKTEQLCKSFETGIGKELHEQLVTQDKQNKHTSYISGPWFDMYLTARDPVVLNFNPFISFNPDPKSEYNDQLTRATNMTVSAIRFLKTLRADLLEPEVFHLNPAKSDTDTFKRFIRFVPSFLSWYGAYLVNAYPLDMSQYYRLFNSTRLPRPHRDELFTDDKARHLLVLRKGHFYIFDVLDQDGNIVSASEIQAHLKYILSDNSPAPEFPLSYLTSENRDIWAELRQKLVSGGNEATLGKVDSAVFCLCLDDFPIRDFVHLSHSMLHGDGTNRWFDKSFNLIIAKDGTAAIHFEHAWGDGVAVLRFFNEVFKDSTQAPAITPQSQPASTDSSVAVQKLNFKLSDALKTGISAAKEKFDATVKSLTIDYIRFQRGGREFLKKQKLSPDSMAQLAFQMAFLRQYGQTVATYESCSTAAFKHGRTETIRPASIFTKTCSEAFVREPSKYSAGELQQMMAKCSTYHNQLTREAAMGQGFDRHLFALRYLAAARGISMPELFLDPAYRQINHNILSTSTLSSPAVNIGCFAPVVPDGFGIGYSVQDNWIGCNVSAYQSRNAREFLQCVEK |
Sequence similarities
Belongs to the carnitine/choline acetyltransferase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length618
- Mass (Da)70,164
- Last updated2024-05-29 v1
- Checksum950E7256E901745D
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
F1N1M7 | F1N1M7_BOVIN | CPT2 | 658 | ||
A0AAA9TSV1 | A0AAA9TSV1_BOVIN | CPT2 | 620 | ||
A0AAA9S9B1 | A0AAA9S9B1_BOVIN | CPT2 | 223 |
Keywords
- Technical term