A0AAA9T0Z0 · A0AAA9T0Z0_BOVIN

  • Protein
    Phosphomannomutase
  • Gene
    PMM2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.

Features

Showing features for active site, binding site.

126320406080100120140160180200220240260
Type
IDPosition(s)Description
Active site12Nucleophile
Binding site12Mg2+ 1 (UniProtKB | ChEBI)
Active site14Proton donor/acceptor
Binding site14Mg2+ 1 (UniProtKB | ChEBI)
Binding site21alpha-D-mannose 1-phosphate (UniProtKB | ChEBI)
Binding site123alpha-D-mannose 1-phosphate (UniProtKB | ChEBI)
Binding site134alpha-D-mannose 1-phosphate (UniProtKB | ChEBI)
Binding site141alpha-D-mannose 1-phosphate (UniProtKB | ChEBI)
Binding site179alpha-D-mannose 1-phosphate (UniProtKB | ChEBI)
Binding site181alpha-D-mannose 1-phosphate (UniProtKB | ChEBI)
Binding site209Mg2+ 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionmetal ion binding
Molecular Functionphosphomannomutase activity
Biological ProcessGDP-mannose biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphomannomutase
  • EC number

Gene names

    • Name
      PMM2

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Hereford
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    A0AAA9T0Z0

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the eukaryotic PMM family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    263
  • Mass (Da)
    30,103
  • Last updated
    2024-05-29 v1
  • Checksum
    1C93F75F26767D3C
MAAPGPALCLFDVDGTLTAPRQKITKDMDCFLQKLRQKIKIGVVGGSDFEKVQEQLGDDVIKKYDYVFPENGLVAYRDGKLLCKQNIQGHLGEALIQDLINYCLSYIAKIKLPKKRGTFIEFRNGMLNVSPIGRSCSQEERIEFYELDQKENIRQKFVEDLRKEFAGKGLTFSIGGQISFDVFPDGWDKRYCLGHVEKDGYKTIYFFGDKTMPVGSLPLSRLVITRTETTGSRPWRQHWSHLVPFKTSGPWCQALTIFYPVYF

Computationally mapped potential isoform sequences

There are 5 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q3SZJ9PMM2_BOVINPMM2246
A0AAA9T6Q6A0AAA9T6Q6_BOVINPMM2243
A0AAA9TEV2A0AAA9TEV2_BOVINPMM2228
A0AAA9TDL7A0AAA9TDL7_BOVINPMM2155
A0AAA9TIZ7A0AAA9TIZ7_BOVINPMM2235

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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