A0AAA9T0Z0 · A0AAA9T0Z0_BOVIN
- ProteinPhosphomannomutase
- GenePMM2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids263 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
Catalytic activity
- alpha-D-mannose 1-phosphate = D-mannose 6-phosphate
Cofactor
Pathway
Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 12 | Nucleophile | |||
Binding site | 12 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Active site | 14 | Proton donor/acceptor | |||
Binding site | 14 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 21 | alpha-D-mannose 1-phosphate (UniProtKB | ChEBI) | |||
Binding site | 123 | alpha-D-mannose 1-phosphate (UniProtKB | ChEBI) | |||
Binding site | 134 | alpha-D-mannose 1-phosphate (UniProtKB | ChEBI) | |||
Binding site | 141 | alpha-D-mannose 1-phosphate (UniProtKB | ChEBI) | |||
Binding site | 179 | alpha-D-mannose 1-phosphate (UniProtKB | ChEBI) | |||
Binding site | 181 | alpha-D-mannose 1-phosphate (UniProtKB | ChEBI) | |||
Binding site | 209 | Mg2+ 1 (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | metal ion binding | |
Molecular Function | phosphomannomutase activity | |
Biological Process | GDP-mannose biosynthetic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphomannomutase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos
Accessions
- Primary accessionA0AAA9T0Z0
Proteomes
Organism-specific databases
Subcellular Location
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length263
- Mass (Da)30,103
- Last updated2024-05-29 v1
- Checksum1C93F75F26767D3C
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q3SZJ9 | PMM2_BOVIN | PMM2 | 246 | ||
A0AAA9T6Q6 | A0AAA9T6Q6_BOVIN | PMM2 | 243 | ||
A0AAA9TEV2 | A0AAA9TEV2_BOVIN | PMM2 | 228 | ||
A0AAA9TDL7 | A0AAA9TDL7_BOVIN | PMM2 | 155 | ||
A0AAA9TIZ7 | A0AAA9TIZ7_BOVIN | PMM2 | 235 |
Keywords
- Technical term