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A0AAA9SMT9 · A0AAA9SMT9_BOVIN

  • Protein
    Mitogen-activated protein kinase kinase kinase 12
  • Gene
    MAP3K12
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

May be an activator of the JNK/SAPK pathway.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site189-197ATP (UniProtKB | ChEBI)
Binding site210ATP (UniProtKB | ChEBI)
Active site294Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular FunctionMAP kinase kinase kinase activity
Biological ProcessJNK cascade
Biological Processprotein autophosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Mitogen-activated protein kinase kinase kinase 12
  • EC number

Gene names

    • Name
      MAP3K12

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Hereford
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    A0AAA9SMT9

Proteomes

Organism-specific databases

Subcellular Location

Family & Domains

Features

Showing features for region, domain, coiled coil, compositional bias.

Type
IDPosition(s)Description
Region78-102Disordered
Domain183-424Protein kinase
Coiled coil477-525
Region583-642Disordered
Region678-918Disordered
Compositional bias791-836Polar residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    918
  • Mass (Da)
    99,041
  • Last updated
    2024-05-29 v1
  • MD5 Checksum
    E257E67D6B797E1226C97A5BB3369BD9
MEDEAGEGPRAWRAHRLPPHWGPEAMACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTQCVLRDVVPLGGQGGGGPSPSPGGEPPPEPFANSVLQLHEQDAGGPGGATGSPESRASRVRADEVRLQCQSGSGFLEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELRHALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKSHPSRGLLHGNTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCAKGPPSPGRSRRGKTRHRKASAKGSCGDLPGLRAAVPPHEPGGPGSPVGLGGGPSAWEACPPALRGLHHDLLLRKMSSSSPDLLSAALGARGRGATGGAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGGAKGEPPPPVGPGDSVGLLGTGREGTAGRGGSRAGSQHLTPAALLYRAAVTRSQKRGISSEEEEGEVDSEVELASSQRWPQGLKMRQSLSTFSSENPSDGEEGTASEPSPSGTPEVGSTNTDERPDERSDDMCSQGSEIPLDPPASEVVTGPEPSSLPVPHHDLLRGEQGPPNPEDSDCDSTELDNANSGEALRPPASLPP

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0AAA9SSF2A0AAA9SSF2_BOVINMAP3K12854
F1N791F1N791_BOVINMAP3K12916
A0A3Q1LZJ9A0A3Q1LZJ9_BOVINMAP3K12885

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias791-836Polar residues

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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