A0AAA9SMT9 · A0AAA9SMT9_BOVIN
- ProteinMitogen-activated protein kinase kinase kinase 12
- GeneMAP3K12
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids918 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
May be an activator of the JNK/SAPK pathway.
Catalytic activity
- L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
Cofactor
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 189-197 | ATP (UniProtKB | ChEBI) | |||
Binding site | 210 | ATP (UniProtKB | ChEBI) | |||
Active site | 294 | Proton acceptor | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | MAP kinase kinase kinase activity | |
Biological Process | JNK cascade | |
Biological Process | protein autophosphorylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMitogen-activated protein kinase kinase kinase 12
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos
Accessions
- Primary accessionA0AAA9SMT9
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for region, domain, coiled coil, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 78-102 | Disordered | |||
Domain | 183-424 | Protein kinase | |||
Coiled coil | 477-525 | ||||
Region | 583-642 | Disordered | |||
Region | 678-918 | Disordered | |||
Compositional bias | 791-836 | Polar residues | |||
Sequence similarities
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length918
- Mass (Da)99,041
- Last updated2024-05-29 v1
- MD5 ChecksumE257E67D6B797E1226C97A5BB3369BD9
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0AAA9SSF2 | A0AAA9SSF2_BOVIN | MAP3K12 | 854 | ||
F1N791 | F1N791_BOVIN | MAP3K12 | 916 | ||
A0A3Q1LZJ9 | A0A3Q1LZJ9_BOVIN | MAP3K12 | 885 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 791-836 | Polar residues | |||
Keywords
- Technical term