A0AAA9SKW9 · A0AAA9SKW9_BOVIN
- ProteinVoltage-dependent P/Q-type calcium channel subunit alpha
- GeneCACNA1A
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids2450 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents.
Catalytic activity
- Ca2+(in) = Ca2+(out)
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 271 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 621 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 1414 | Ca2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | voltage-gated calcium channel complex | |
Molecular Function | metal ion binding | |
Molecular Function | voltage-gated calcium channel activity |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameVoltage-dependent P/Q-type calcium channel subunit alpha
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos
Accessions
- Primary accessionA0AAA9SKW9
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 92-112 | Helical | |||
Transmembrane | 124-142 | Helical | |||
Transmembrane | 175-198 | Helical | |||
Transmembrane | 257-278 | Helical | |||
Transmembrane | 290-312 | Helical | |||
Transmembrane | 441-460 | Helical | |||
Transmembrane | 472-492 | Helical | |||
Transmembrane | 567-589 | Helical | |||
Transmembrane | 643-667 | Helical | |||
Transmembrane | 1197-1216 | Helical | |||
Transmembrane | 1236-1257 | Helical | |||
Transmembrane | 1269-1286 | Helical | |||
Transmembrane | 1331-1353 | Helical | |||
Transmembrane | 1443-1468 | Helical | |||
Transmembrane | 1524-1542 | Helical | |||
Transmembrane | 1554-1577 | Helical | |||
Transmembrane | 1645-1663 | Helical | |||
Transmembrane | 1741-1765 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for glycosylation.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Glycosylation | 236 | N-linked (GlcNAc...) asparagine | |||
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for coiled coil, region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Coiled coil | 663-699 | ||||
Region | 768-1175 | Disordered | |||
Compositional bias | 781-796 | Polar residues | |||
Compositional bias | 806-828 | Basic and acidic residues | |||
Compositional bias | 847-864 | Basic and acidic residues | |||
Compositional bias | 871-895 | Basic and acidic residues | |||
Compositional bias | 904-988 | Basic and acidic residues | |||
Compositional bias | 991-1008 | Polar residues | |||
Compositional bias | 1026-1042 | Polar residues | |||
Compositional bias | 1059-1084 | Polar residues | |||
Compositional bias | 1094-1116 | Polar residues | |||
Domain | 1902-1936 | Voltage-dependent calcium channel alpha-1 subunit IQ | |||
Region | 1943-1978 | Disordered | |||
Compositional bias | 1998-2021 | Polar residues | |||
Region | 1998-2450 | Disordered | |||
Compositional bias | 2062-2078 | Polar residues | |||
Compositional bias | 2089-2108 | Basic and acidic residues | |||
Compositional bias | 2159-2175 | Basic residues | |||
Compositional bias | 2176-2212 | Basic and acidic residues | |||
Compositional bias | 2213-2250 | Polar residues | |||
Compositional bias | 2261-2275 | Polar residues | |||
Compositional bias | 2347-2361 | Basic and acidic residues | |||
Sequence similarities
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1A subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,450
- Mass (Da)275,962
- Last updated2024-05-29 v1
- Checksum2FFF410014C15265
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0AAA9RZH4 | A0AAA9RZH4_BOVIN | CACNA1A | 2502 | ||
A0AAA9SVR7 | A0AAA9SVR7_BOVIN | CACNA1A | 2485 | ||
A0A3Q1LN55 | A0A3Q1LN55_BOVIN | CACNA1A | 2329 | ||
F1N1E0 | F1N1E0_BOVIN | CACNA1A | 2498 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 781-796 | Polar residues | |||
Compositional bias | 806-828 | Basic and acidic residues | |||
Compositional bias | 847-864 | Basic and acidic residues | |||
Compositional bias | 871-895 | Basic and acidic residues | |||
Compositional bias | 904-988 | Basic and acidic residues | |||
Compositional bias | 991-1008 | Polar residues | |||
Compositional bias | 1026-1042 | Polar residues | |||
Compositional bias | 1059-1084 | Polar residues | |||
Compositional bias | 1094-1116 | Polar residues | |||
Compositional bias | 1998-2021 | Polar residues | |||
Compositional bias | 2062-2078 | Polar residues | |||
Compositional bias | 2089-2108 | Basic and acidic residues | |||
Compositional bias | 2159-2175 | Basic residues | |||
Compositional bias | 2176-2212 | Basic and acidic residues | |||
Compositional bias | 2213-2250 | Polar residues | |||
Compositional bias | 2261-2275 | Polar residues | |||
Compositional bias | 2347-2361 | Basic and acidic residues | |||
Keywords
- Technical term