A0AAA9SKW9 · A0AAA9SKW9_BOVIN

  • Protein
    Voltage-dependent P/Q-type calcium channel subunit alpha
  • Gene
    CACNA1A
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents.

Catalytic activity

Features

Showing features for binding site.

124502004006008001,0001,2001,4001,6001,8002,0002,2002,400
TypeIDPosition(s)Description
Binding site271Ca2+ (UniProtKB | ChEBI)
Binding site621Ca2+ (UniProtKB | ChEBI)
Binding site1414Ca2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentvoltage-gated calcium channel complex
Molecular Functionmetal ion binding
Molecular Functionvoltage-gated calcium channel activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Voltage-dependent P/Q-type calcium channel subunit alpha

Gene names

    • Name
      CACNA1A

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Hereford
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    A0AAA9SKW9

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane92-112Helical
Transmembrane124-142Helical
Transmembrane175-198Helical
Transmembrane257-278Helical
Transmembrane290-312Helical
Transmembrane441-460Helical
Transmembrane472-492Helical
Transmembrane567-589Helical
Transmembrane643-667Helical
Transmembrane1197-1216Helical
Transmembrane1236-1257Helical
Transmembrane1269-1286Helical
Transmembrane1331-1353Helical
Transmembrane1443-1468Helical
Transmembrane1524-1542Helical
Transmembrane1554-1577Helical
Transmembrane1645-1663Helical
Transmembrane1741-1765Helical

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for glycosylation.

TypeIDPosition(s)Description
Glycosylation236N-linked (GlcNAc...) asparagine

Keywords

Family & Domains

Features

Showing features for coiled coil, region, compositional bias, domain.

Type
IDPosition(s)Description
Coiled coil663-699
Region768-1175Disordered
Compositional bias781-796Polar residues
Compositional bias806-828Basic and acidic residues
Compositional bias847-864Basic and acidic residues
Compositional bias871-895Basic and acidic residues
Compositional bias904-988Basic and acidic residues
Compositional bias991-1008Polar residues
Compositional bias1026-1042Polar residues
Compositional bias1059-1084Polar residues
Compositional bias1094-1116Polar residues
Domain1902-1936Voltage-dependent calcium channel alpha-1 subunit IQ
Region1943-1978Disordered
Compositional bias1998-2021Polar residues
Region1998-2450Disordered
Compositional bias2062-2078Polar residues
Compositional bias2089-2108Basic and acidic residues
Compositional bias2159-2175Basic residues
Compositional bias2176-2212Basic and acidic residues
Compositional bias2213-2250Polar residues
Compositional bias2261-2275Polar residues
Compositional bias2347-2361Basic and acidic residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,450
  • Mass (Da)
    275,962
  • Last updated
    2024-05-29 v1
  • Checksum
    2FFF410014C15265
MARFGDEMPARYGGGGSGAAAGVVVGAGGGRGAGGSRQGGQPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSEDNVDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRATIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKLALQKAKEVAEVSPLSAANMSIAVKEQQKNQKPAKSVWEQRTSEMRKQNLLASREALYNEMDPDERWKASYARHLRPDMKTHLDRPLVVDPQENRNNNTNKSRAAEPTVDQRLGQQRAEDFLRKQARYHDRARDPSSSVGLDTRRPWAGSQEAELSREGPYGRESDHHAREGGLEQPGFWEGEAERGKAGDPHRRHAHRQAGSRESRSGSPRTGADGEPRRHRAHRRPGDEAPDDKADRRSRHREGSRPARGGEGESEGPDGGGERRRRHRHGPPPAYDADMRREDKERRHRRRKENQGSGVPVSGPNLSTTRPIQQDLGRQDPPLAEDIDNMKNNKLATAESASPHDSLSHAGLPQSPAKMGNSMDPGPTPAPTTTATNPQNAVSRRTANNPGNPSNPGPPKTPENSLIVTNPSSTQANSAKTARKPDHTTVDIPPACPPPLNHTIIQVNKNANPDPLPKKEEEKKEEEEDDPGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTHECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAACGRIHYKDMYSLLRVISPPLGLGKKCPHRVACKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAMREEQNRTPLMFQRMEPPSPTQEGGPGQNALPSTQLDPGGGLMAHESGMKESPSWVTQRAQEMFQKTGTWSPERGPPTDMPNSQPNSQSVEMREMGRDGYSDSEHYFPVEGQARAASMPRLPAENQRRRGRPRGNNLSTISDTSPMKRSASVLGPKARRLDDYSLERVPPEENQRHHQRRRDRGHRTSERSLGRYTDVDTGLGTDLSMTTQSGDLPSKERDQERGRPKDRKHRQHHHHHHHHHPPPPDKERYTQERPEHGRPRARDQRWSRSPSEGREHMAHRQGSSSVSGSPAPSTSGTSTPRRGRRQLPQTPSTPRPHVSYSPVIRKAGGSGPQQQQQPAARPGRTAPSGPRRYPGPVAEPLAGERPPTGGHGSSRSPAMERRIPGPARSESPRAPCRHGGARWPASGAHAAEGPPGPRHHHGYYRGSDYDEPDGPGGGGGEEEEPRAAAYDAPPPARHGCSPRTPRAAGPACASPSRHGRRLPNGYYPAHGLARPRGPGSRKGLHEAYSETDDDDWC

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0AAA9RZH4A0AAA9RZH4_BOVINCACNA1A2502
A0AAA9SVR7A0AAA9SVR7_BOVINCACNA1A2485
A0A3Q1LN55A0A3Q1LN55_BOVINCACNA1A2329
F1N1E0F1N1E0_BOVINCACNA1A2498

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias781-796Polar residues
Compositional bias806-828Basic and acidic residues
Compositional bias847-864Basic and acidic residues
Compositional bias871-895Basic and acidic residues
Compositional bias904-988Basic and acidic residues
Compositional bias991-1008Polar residues
Compositional bias1026-1042Polar residues
Compositional bias1059-1084Polar residues
Compositional bias1094-1116Polar residues
Compositional bias1998-2021Polar residues
Compositional bias2062-2078Polar residues
Compositional bias2089-2108Basic and acidic residues
Compositional bias2159-2175Basic residues
Compositional bias2176-2212Basic and acidic residues
Compositional bias2213-2250Polar residues
Compositional bias2261-2275Polar residues
Compositional bias2347-2361Basic and acidic residues

Keywords

Genome annotation databases

Similar Proteins

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