A0AAA9SD97 · A0AAA9SD97_BOVIN

  • Protein
    DNA 3'-5' helicase
  • Gene
    WRN
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

Catalytic activity

  • Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.
    EC:5.6.2.4 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular Function3'-5' DNA helicase activity
Molecular Function3'-5' exonuclease activity
Molecular FunctionATP binding
Molecular FunctionDNA binding
Molecular Functionisomerase activity
Molecular Functionmetal ion binding
Biological ProcessDNA recombination
Biological ProcessDNA repair
Biological ProcessDNA replication

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA 3'-5' helicase
  • EC number

Gene names

    • Name
      WRN

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Hereford
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    A0AAA9SD97

Proteomes

Organism-specific databases

Subcellular Location

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region408-432Disordered
Region473-497Disordered
Compositional bias474-494Acidic residues
Domain529-695Helicase ATP-binding
Domain720-871Helicase C-terminal
Domain1121-1200HRDC
Compositional bias1332-1375Basic and acidic residues
Region1332-1409Disordered

Sequence similarities

Belongs to the helicase family. RecQ subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,409
  • Mass (Da)
    159,831
  • Last updated
    2024-05-29 v1
  • MD5 Checksum
    CF6F7FC25DDA33679FA3D7AB982651DB
MDLLKMSEQTLERGGQRKLPDWMSVQKSYTVEEKKASVRKSVLEDHLPFLEFTGSTVYSYEANDCSLLSEDISMSLSDGDVVGFDIEWPPFKKGTLSRVALIQLCVAESKCYLFHISSMSGFPQGLKMLLENEAIKKAGVGIEQDQWKLLRDFDINLKSIVELTDVANEKLKCIETWSLNGLVKYLFGKQLLKDRSIRCSDWSRFPLTEDQKVYAATDAYAGFIIYQKLANLSDPVQIFVKSKEEEILPSDVKKQLTSISKEMMDLAERLPDTFGKLENPQRVSLLLKDISENLYSLRMMMFGSPEKELRPSDNFHLLPLEEPTAGEAQEKQIRAHNIFPEVEDEAWDATPDGLIEHDGEKVLGNQMKQEDGFEDELEGKKLEENTERNCLMSLDVTEEELQLWEQQAEEKHLTDVTCTSPEHSSSKDNEEDLSYIIESDEDLEMEMLKSLENLKSGMVDPNHSKCIEMEKNLDLPSEEDDEDENEAVEEEKETDEDCLLPRPTEKQINCLKTYFGHSSFKPVQWKVIHSVLEERRDNVVVMTTGYGKSLCFQYPPVYAGGIGLVISPLISLMEDQVLQLEISSIPACFLGSAQSKNVVEDIKLGKYRIVYLTPEFCSGNLELLRQLEANIGITLIAVDEAHCISEWGHDFRNSFRDLGCLKAEFPKVPIVALTATAGSSVREDIVCCLNLKDPQITCTGFDRPNLYLEVGRKTGDILQDLKQFLVCKSSSAWEFEGPTIIYCPSRKMTEQVTAELKKLKLACGTYHAGLSINLRKQVHHRFMRDEIQCVIATVAFGMGINKADIRQVIHYGAPKEMESYYQEIGRAGRDGLQSSCHVLWAPADMNLNRCLLSEIRNEKFRLYKLKMMGKMEKYLYSSKCRRQIILSHFEDKQLRKASVGIMGTENCCDNCKSRLDHCFSLEDSEDTQDFGPQAFQFLSAVTILGGRFGIGIPILFLRGSNSQRLEDRYRSHSVFGTGKDHTEKWWKALSRQLIIEGFLAEVPGHSKYVKICTLTEKGRNWFAKAKTESPPRLFLQTNEQLCPRTFLPSSKAVSSGTEEHVSDQVPVKLTSEKQFNLDQLYSYKVHDKISSGSNSPKNSIIVSSPRKYYKSSEPVISAQEQETQTALYGELVAARQKHANMMDVPPAILATNKILLDMAKMRPTTVENVKRIDGVSEGKAVMLAPLLEVIRRFCQINSVQTDLFSSSELQEEEKKNLVLENKANSLSPSMAITYFFFQEKKMSLKDTAEKRTLPLTAVGMHLSQAMKAGYPVDTERAGLTPEIQKIIADVIRNPPINSDTNKINLIRIYVPENIDTYLIHMTIKILEKDGDHRMRCHSSCDPNKKRRFPDPEESSSNSKRTKEEVDTEAKTSSEMSKRKLPWWFAKGNDTLPDTSKKSVAKTKNKGLFS

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0AAA9U213A0AAA9U213_BOVINWRN1373
E1BEE6E1BEE6_BOVINWRN1404

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias474-494Acidic residues
Compositional bias1332-1375Basic and acidic residues

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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