A0AAA9S645 · A0AAA9S645_BOVIN

  • Protein
    Cystic fibrosis transmembrane conductance regulator
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

Catalytic activity

GO annotations

AspectTerm
Cellular Componentapical plasma membrane
Cellular Componentchloride channel complex
Cellular Componentearly endosome membrane
Cellular Componentendoplasmic reticulum membrane
Cellular Componentrecycling endosome membrane
Molecular FunctionABC-type transporter activity
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functionchloride channel activity
Molecular Functionisomerase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cystic fibrosis transmembrane conductance regulator
  • EC number
  • Alternative names
    • ATP-binding cassette sub-family C member 7
    • Channel conductance-controlling ATPase
    • cAMP-dependent chloride channel

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Hereford
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    A0AAA9S645

Proteomes

Subcellular Location

Apical cell membrane
; Multi-pass membrane protein
Early endosome membrane
; Multi-pass membrane protein
Endoplasmic reticulum membrane
; Multi-pass membrane protein
Recycling endosome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane91-114Helical
Transmembrane168-188Helical
Transmembrane194-215Helical
Transmembrane275-295Helical
Transmembrane664-683Helical

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Monomer; does not require oligomerization for channel activity. May form oligomers in the membrane. Interacts with SLC26A3, SLC26A6 and NHERF1. Interacts with SHANK2. Interacts with MYO6. Interacts (via C-terminus) with GOPC (via PDZ domain); this promotes CFTR internalization and thereby decreases channel activity. Interacts with SLC4A7 through NHERF1. Found in a complex with MYO5B and RAB11A. Interacts with ANO1. Interacts with SLC26A8. Interacts with AHCYL1; the interaction increases CFTR activity. Interacts with CSE1L. The core-glycosylated form interacts with GORASP2 (via PDZ GRASP-type 1 domain) in respone to ER stress. Interacts with MARCHF2; the interaction leads to CFTR ubiqtuitination and degradation.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain55-315ABC transmembrane type-1
Domain367-590ABC transporter

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    730
  • Mass (Da)
    81,779
  • Last updated
    2024-05-29 v1
  • Checksum
    D3E8CD8D94409232
MYSVLPEDRSQHLGEELQGYWDQEVLRAQKDAREPSLMKAIIKCYGKSYLVWGMLTFLEEGTRVVQPIFLGKMISYFENYNPTDSAALHEAYGYAAGLSACVLLWAVLHHLYFYHMQRVGMRLRVAVCHMIYRKTLRLSSSAMGKTTTGQIVNLLSNDVNRFDQVTTLLHYLWVGPLQVIAVTALLWMEIGMSCLAGMAVLIILLLLQSCFGMSFSSLRSRTAALTDDRIRTMSEVITGIRTVKMNVWEQSFINLITRLGRKEISKILRSSYLRAMNLTSFFAVSKIMIFVTFIANELLDNLITASQVFVVVMLFEALRFSSTLYFPMAIEKVSEAVVSIRRIKNFLLLDEVSQCYPQLPSDGKTIVDVQAFSASWEKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLNALLGELPPSQGQVSVHGRIAYVSQQPWVFPGTVKSNILFGKKYKEDRYEEVIRACALEKDLQLLEEGDLTEIGERGTPLSEGQKARVRLARAVYQDADIYLLDDPLSAVDAGVSRHLFEQCVCQALKDKITILVTHQLQHLKDASQILVLKDGITVERGTYSEFLKSGIDIFSLFEKGNEQSEPSSVPGAPSLISESLVQSLKSPRPSLKDAAPEDQETENIQVTLPVEDHLEGKVGFKTYKNYFTAGADWPIIIFLILVNIAAQVAYVLQDWWLAFWANVQNGLYFGVYVKEDEDVVFVLNWYLSVYSGKVESSAP

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0AAA9TUR1A0AAA9TUR1_BOVIN1312
A0A3Q1NKH4A0A3Q1NKH4_BOVIN221
A0AAA9TK80A0AAA9TK80_BOVIN223
A0A3Q1MQ90A0A3Q1MQ90_BOVIN147

Keywords

Genome annotation databases

Similar Proteins

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