A0AAA9S645 · A0AAA9S645_BOVIN
- ProteinCystic fibrosis transmembrane conductance regulator
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids730 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- ATP + H2O = ADP + phosphate + H+This reaction proceeds in the forward direction.
- chloride(in) = chloride(out)
- hydrogencarbonate(in) = hydrogencarbonate(out)
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | apical plasma membrane | |
Cellular Component | chloride channel complex | |
Cellular Component | early endosome membrane | |
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | recycling endosome membrane | |
Molecular Function | ABC-type transporter activity | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | chloride channel activity | |
Molecular Function | isomerase activity |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCystic fibrosis transmembrane conductance regulator
- EC number
- Alternative names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos
Accessions
- Primary accessionA0AAA9S645
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Apical cell membrane ; Multi-pass membrane protein
Early endosome membrane ; Multi-pass membrane protein
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Recycling endosome membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 91-114 | Helical | |||
Transmembrane | 168-188 | Helical | |||
Transmembrane | 194-215 | Helical | |||
Transmembrane | 275-295 | Helical | |||
Transmembrane | 664-683 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Monomer; does not require oligomerization for channel activity. May form oligomers in the membrane. Interacts with SLC26A3, SLC26A6 and NHERF1. Interacts with SHANK2. Interacts with MYO6. Interacts (via C-terminus) with GOPC (via PDZ domain); this promotes CFTR internalization and thereby decreases channel activity. Interacts with SLC4A7 through NHERF1. Found in a complex with MYO5B and RAB11A. Interacts with ANO1. Interacts with SLC26A8. Interacts with AHCYL1; the interaction increases CFTR activity. Interacts with CSE1L. The core-glycosylated form interacts with GORASP2 (via PDZ GRASP-type 1 domain) in respone to ER stress. Interacts with MARCHF2; the interaction leads to CFTR ubiqtuitination and degradation.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 55-315 | ABC transmembrane type-1 | |||
Domain | 367-590 | ABC transporter | |||
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length730
- Mass (Da)81,779
- Last updated2024-05-29 v1
- ChecksumD3E8CD8D94409232
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0AAA9TUR1 | A0AAA9TUR1_BOVIN | 1312 | |||
A0A3Q1NKH4 | A0A3Q1NKH4_BOVIN | 221 | |||
A0AAA9TK80 | A0AAA9TK80_BOVIN | 223 | |||
A0A3Q1MQ90 | A0A3Q1MQ90_BOVIN | 147 |
Keywords
- Technical term