A0AA96Y4J0 · A0AA96Y4J0_9PSED

  • Protein
    Aconitate hydratase B
  • Gene
    acnB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster per subunit.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.
Organic acid metabolism; propanoate degradation.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site191substrate
Binding site244-246substrate
Binding site414-416substrate
Binding site498substrate
Binding site710[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site769[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site772[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site791substrate
Binding site796substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Function2-methylisocitrate dehydratase activity
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionaconitate hydratase activity
Molecular Functionmetal ion binding
Molecular FunctionRNA binding
Biological Processpropionate catabolic process, 2-methylcitrate cycle
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Aconitate hydratase B
  • EC number
  • Alternative names
    • 2-methylisocitrate dehydratase

Gene names

    • Name
      acnB
    • ORF names
      QOM08_15045

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • P105
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas

Accessions

  • Primary accession
    A0AA96Y4J0

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-156Aconitase B HEAT-like
Domain169-382Aconitase B swivel
Domain472-696Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Domain697-818Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha

Sequence similarities

Belongs to the aconitase/IPM isomerase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    866
  • Mass (Da)
    93,662
  • Last updated
    2024-03-27 v1
  • Checksum
    27F4920F91F07442
MLEAYRKHIEERAALGIVPQPLNAEQTAGLIELLKNPPAGEEAFLVDLITNRVPPGVDEAAYVKAGFLSALAKGEAQSPLLDKKRAVELLGTMQGGYNIVTLVDLLDDAELAPVAAEELKHTLLMFDAFHDVAEKARNGNVHAKGVLQSWADGEWFKNRPVLADKISLRVFKVTGETNTDDLSPAPDAWSRPDIPLHALAMLKMARDGIVPDEQGKTGPMKQIEEMRGQGFPIAYVGDVVGTGSSRKSATNSVLWFFGDDVPYVPNKRAGGFCFGSKIAPIFYNTMEDAGALPIEFDVSNMHMGDVIDLYPHAGKVCKHGTDEVLATFEMKTPVLLDEVRAGGRIPLIIGRGLTEKARAELGLPASDLFKKPEAPAESTKGFTLAQKMVGKACGVTGVRPGTYCEPKMTTVGSQDTTGPMTRDELKDLACLGFSTDLVMQSFCHTAAYPKPIDVTTHHTLPDFIMTRGGVSLRPGDGIIHSWLNRMLLPDTVGTGGDSHTRFPIGISFPAGSGLVAFAAATGVMPLDMPESILVRFKGKLQPGVTLRDLVHAIPYYAIQKGLLTVEKKGKKNAFSGRILEIEGLETLTVEQAFELSDASAERSAAGCTIKLSKESIAEYLQSNITLLRWMIGEGYGDARTLERRAQAMEAWLANPELLEADKDAEYAEVIEIDLADVKEPVLCAPNDPDDARLLSSVAGQKIDEVFIGSCMTNIGHFRAAGKLLEQVKGQLPTRLWLSPPTKMDAHQLTEEGYYGIYGKAGARMEMPGCSLCMGNQARVEPNSTVVSTSTRNFPNRLGDGANVYLASAELASVASILGRLPTVEEYMEYAGKIDSMAADVYRYLSFDQIAEFREAAANANIPVVQA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP126693
EMBL· GenBank· DDBJ
WNZ81266.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp