A0AA96XZ64 · A0AA96XZ64_9PSED

  • Protein
    Adenylosuccinate lyase
  • Gene
    purB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N6-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.

Catalytic activity

Pathway

Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.
Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionN6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity
Biological ProcessIMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenylosuccinate lyase
  • EC number
  • Short names
    ASL
  • Alternative names
    • Adenylosuccinase

Gene names

    • Name
      purB
    • ORF names
      QOM08_10190

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • P105
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas

Accessions

  • Primary accession
    A0AA96XZ64

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain14-313Fumarate lyase N-terminal
Domain332-446Adenylosuccinate lyase PurB C-terminal

Sequence similarities

Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    456
  • Mass (Da)
    50,712
  • Last updated
    2024-03-27 v1
  • Checksum
    3464EA849408843D
MQLSSLTAVSPVDGRYAGKTQALRPIFSEYGLIRARVLVEVRWLQRLAAHPGIAEVPAFSAQANAVLNALAENFVLEHAERVKEIERTTNHDVKAIEYLLKEQAAKLPELANVSEFIHFACTSEDINNLSHALMLREGRDDVMLPLMRQTAQAIRELAIRFADVPMLSRTHGQPASPTTLGKELANVVYRLERQIAQVAAVPLLGKINGAVGNYNAHLSAYPDIDWEANARAFIEDELGLSFNPYTTQIEPHDYIAELFDAIARFNTILIDFDRDIWGYISLGYFKQRTIAGEIGSSTMPHKVNPIDFENSEGNLGIANALFQHLASKLPISRWQRDLTDSTVLRNLGVGFAHSVIAYEASLKGISKLELNEQKIAADLDACWEVLAEPIQTVMRRYNIENPYEKLKELTRGKGISPEALQTFIDGLDMPAEARAELKKLTPANYIGNAAAQAKRI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP126693
EMBL· GenBank· DDBJ
WNZ80432.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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