A0AA96X6G8 · A0AA96X6G8_9GAMM
- ProteinATP-dependent dethiobiotin synthetase BioD
- GenebioD
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids232 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
Catalytic activity
- (7R,8S)-7,8-diammoniononanoate + CO2 + ATP = (4R,5S)-dethiobiotin + ADP + phosphate + 3 H+
Cofactor
Pathway
Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 13-18 | ATP (UniProtKB | ChEBI) | |||
Binding site | 17 | Mg2+ (UniProtKB | ChEBI) | |||
Active site | 38 | ||||
Binding site | 42 | substrate | |||
Binding site | 55 | ATP (UniProtKB | ChEBI) | |||
Binding site | 55 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 117 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 117-120 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | dethiobiotin synthase activity | |
Molecular Function | magnesium ion binding | |
Biological Process | biotin biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP-dependent dethiobiotin synthetase BioD
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Cellvibrionales > Microbulbiferaceae > Microbulbifer
Accessions
- Primary accessionA0AA96X6G8
Subcellular Location
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length232
- Mass (Da)24,457
- Last updated2024-03-27 v1
- Checksum1048A0962FD22641
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP128433 EMBL· GenBank· DDBJ | WNZ56770.1 EMBL· GenBank· DDBJ | Genomic DNA |