A0AA96VNN8 · A0AA96VNN8_9BACT

  • Protein
    Ribose-phosphate pyrophosphokinase
  • Gene
    prs
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 2 Mg2+ ions per subunit.

Pathway

Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site37-39ATP (UniProtKB | ChEBI)
Binding site96-97ATP (UniProtKB | ChEBI)
Binding site130Mg2+ (UniProtKB | ChEBI)
Binding site169Mg2+ (UniProtKB | ChEBI)
Active site192
Binding site194D-ribose 5-phosphate (UniProtKB | ChEBI)
Binding site218D-ribose 5-phosphate (UniProtKB | ChEBI)
Binding site222-226D-ribose 5-phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionkinase activity
Molecular Functionmagnesium ion binding
Molecular Functionribose phosphate diphosphokinase activity
Biological Process5-phosphoribose 1-diphosphate biosynthetic process
Biological Processnucleotide biosynthetic process
Biological Processribonucleoside monophosphate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribose-phosphate pyrophosphokinase
  • EC number
  • Short names
    RPPK
  • Alternative names
    • 5-phospho-D-ribosyl alpha-1-diphosphate synthase
    • Phosphoribosyl diphosphate synthase
    • Phosphoribosyl pyrophosphate synthase
      (P-Rib-PP synthase
      ; PRPP synthase
      ; PRPPase
      )

Gene names

    • Name
      prs
    • ORF names
      SUSP_000346

Organism names

  • Taxonomic identifier
  • Strain
    • SP
  • Taxonomic lineage
    Bacteria > Campylobacterota > Epsilonproteobacteria > Campylobacterales > Sulfurospirillaceae > Sulfurospirillum

Accessions

  • Primary accession
    A0AA96VNN8

Subcellular Location

Keywords

Interaction

Subunit

Homohexamer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-120Ribose-phosphate pyrophosphokinase N-terminal

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    309
  • Mass (Da)
    33,484
  • Last updated
    2024-03-27 v1
  • Checksum
    39B20939427C4BA9
MRGYKVFAGTANPEFAKRVAKHLSLPLSAAEIKTFSDGEISVQISESVRGKDVFIIQSTCAPANVNLMELLILTDALRRSSANSITAIMPYFGYARQDRKAAPRVPITAKLVANMIQTAGIDRVVTIDLHAGQIQGFFDIPVDNLYGSIIFNDYVKAKNLKNPIIASPDIGGVARARSFAKLLGVDMVIVDKRREKANESEVMNIIGDVSGKDVILVDDMIDTAGTIVKAAEVLKKRGATSVMACCTHAVLSGPAYERIAKGELDELVVTDTIPLKEANPKIKVLSVAPVFAEVIRRVYHNESVNGLFI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP118373
EMBL· GenBank· DDBJ
WNY97928.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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