A0AA96UK92 · A0AA96UK92_9BACI

  • Protein
    4-hydroxy-tetrahydrodipicolinate reductase
  • Gene
    dapB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site12-17NAD+ (UniProtKB | ChEBI)
Binding site42NAD+ (UniProtKB | ChEBI)
Binding site100-102NAD+ (UniProtKB | ChEBI)
Binding site126-129NAD+ (UniProtKB | ChEBI)
Active site156Proton donor/acceptor
Binding site157(S)-2,3,4,5-tetrahydrodipicolinate (UniProtKB | ChEBI)
Active site160Proton donor
Binding site166-167(S)-2,3,4,5-tetrahydrodipicolinate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function4-hydroxy-tetrahydrodipicolinate reductase
Molecular FunctionNAD binding
Molecular FunctionNADP binding
Molecular Functionoxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor
Biological Processdiaminopimelate biosynthetic process
Biological Processlysine biosynthetic process via diaminopimelate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    4-hydroxy-tetrahydrodipicolinate reductase
  • EC number
  • Short names
    HTPA reductase

Gene names

    • Name
      dapB
    • ORF names
      RUI02_11185

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • TSA-4
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Bacillaceae > Bacillus

Accessions

  • Primary accession
    A0AA96UK92

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain6-129Dihydrodipicolinate reductase N-terminal
Domain132-265Dihydrodipicolinate reductase C-terminal

Sequence similarities

Belongs to the DapB family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    267
  • Mass (Da)
    29,474
  • Last updated
    2024-03-27 v1
  • Checksum
    2EC536E27665EC00
MSNETIKVVIAGPRGRMGQEAVKLAERTPHFDLVGAIDHTYDQQKLSDVMPVESDAFIYTDIHACFTETQPDVLIDLTTPEIGKVHTKIALEHGVRPVVGTTGFSEADLKELTSLTEEKGIGAIIAPNFALGAILMMKFSKMAANYFEDVEIIELHHDQKLDAPSGTALKTAEMISEVRKEKQQGHPDEKEILPGARGAEQNGIRLHSVRLPGLIAHQEVMFGMDGQTLQIRHDSYNRASFMSGVKLSVEQVMKIDQLVYGLENIID

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP136099
EMBL· GenBank· DDBJ
WNW98350.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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