A0AA96UK78 · A0AA96UK78_9BACI

  • Protein
    Endonuclease III
  • Gene
    nth
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site189[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site196[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site199[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site205[4Fe-4S] cluster (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular FunctionDNA binding
Molecular FunctionDNA N-glycosylase activity
Molecular FunctionDNA-(apurinic or apyrimidinic site) endonuclease activity
Molecular Functionendonuclease activity
Molecular Functionlyase activity
Molecular Functionmetal ion binding
Biological Processbase-excision repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Endonuclease III
  • EC number
  • Alternative names
    • DNA-(apurinic or apyrimidinic site) lyase

Gene names

    • Name
      nth
    • ORF names
      RUI02_11110

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • TSA-4
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Bacillaceae > Bacillus

Accessions

  • Primary accession
    A0AA96UK78

Structure

3D structure databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain39-187HhH-GPD

Sequence similarities

Belongs to the Nth/MutY family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    219
  • Mass (Da)
    25,000
  • Last updated
    2024-03-27 v1
  • Checksum
    C38C66DA7948BA40
MLNLKQIEFCLDKIGDMFPHAECELVHSNPFELVVAVALSAQCTDALVNRVTKTLFQKYKRPEDYLAVPLEELQQDIKSIGLYRNKAKNIQKLSKMIIEDYGGEVPRDRDELVKLPGVGRKTANVVVSVAFGVPAIAVDTHVERVSKRLGICRWKDSVLEVEKTLMRKVPKEDWSVTHHRLIFFGRYHCKAQSPRCAECPLLSLCREGQKRDKKGLVKR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP136099
EMBL· GenBank· DDBJ
WNW98335.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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