A0AA91TXV8 · A0AA91TXV8_WOLPI

  • Protein
    Aspartate carbamoyltransferase
  • Gene
    pyrB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the condensation of carbamoyl phosphate and aspartate to form carbamoyl aspartate and inorganic phosphate, the committed step in the de novo pyrimidine nucleotide biosynthesis pathway.
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site54carbamoyl phosphate (UniProtKB | ChEBI)
Binding site55carbamoyl phosphate (UniProtKB | ChEBI)
Binding site82L-aspartate (UniProtKB | ChEBI)
Binding site104carbamoyl phosphate (UniProtKB | ChEBI)
Binding site132carbamoyl phosphate (UniProtKB | ChEBI)
Binding site135carbamoyl phosphate (UniProtKB | ChEBI)
Binding site165L-aspartate (UniProtKB | ChEBI)
Binding site218L-aspartate (UniProtKB | ChEBI)
Binding site257carbamoyl phosphate (UniProtKB | ChEBI)
Binding site258carbamoyl phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionamino acid binding
Molecular Functionaspartate carbamoyltransferase activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Processamino acid metabolic process
Biological Processpyrimidine ribonucleotide biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Aspartate carbamoyltransferase
  • EC number
  • Alternative names
    • Aspartate transcarbamylase
      (ATCase
      )

Gene names

    • Name
      pyrB
    • ORF names
      BTO27_02310

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • wAus
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Rickettsiales > Anaplasmataceae > Wolbachieae > Wolbachia

Accessions

  • Primary accession
    A0AA91TXV8

Proteomes

Interaction

Subunit

Heterododecamer (2C3:3R2) of six catalytic PyrB chains organized as two trimers (C3), and six regulatory PyrI chains organized as three dimers (R2).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-143Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Domain151-291Aspartate/ornithine carbamoyltransferase Asp/Orn-binding

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    295
  • Mass (Da)
    32,975
  • Last updated
    2024-03-27 v1
  • Checksum
    8F9184336C227B8B
MDKRRNLLNISDLTIGDVENITKLANQYLEEKVENSHVLKNKIVINLFFEDSTRTLASFEIAAKSLGANVITLPIKSSSINKGEDLKDMIKTLNAMNPDYMIIRHKSSGIINTLAKHVNCSLINAGDGSSEHPTQALADYLVIISHKKQIKNLKIVICGDILHSRVARSNIRLLKMFGAKISLVAPPALMCKHFSEVDSLHYSLTEGIKDADVIMLLRLQKERMNNNSSEKEYFHLYGLDAQKLSHAKPDAIVMHPGPINRGIEISNDIEDCVILQQVKFGLATRKAVLHYLINV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MRWX01000015
EMBL· GenBank· DDBJ
PBQ28155.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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