A0AA88VDJ2 · A0AA88VDJ2_9ASTE

  • Protein
    DNA-(apurinic or apyrimidinic site) endonuclease 2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Probably binds two magnesium or manganese ions per subunit.
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for active site, binding site, site.

1890100200300400500600700800
Type
IDPosition(s)Description
Active site157
Active site198Proton donor/acceptor
Binding site198Mg2+ 1 (UniProtKB | ChEBI)
Binding site200Mg2+ 1 (UniProtKB | ChEBI)
Site200Transition state stabilizer
Site269Important for catalytic activity
Binding site326Mg2+ 1 (UniProtKB | ChEBI)
Active site327Proton acceptor
Binding site327Mg2+ 1 (UniProtKB | ChEBI)
Site327Interaction with DNA substrate

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA-(apurinic or apyrimidinic site) endonuclease activity
Molecular Functiondouble-stranded DNA 3'-5' DNA exonuclease activity
Molecular Functionphosphoric diester hydrolase activity
Molecular Functionzinc ion binding
Biological Processbase-excision repair

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    DNA-(apurinic or apyrimidinic site) endonuclease 2

Gene names

    • ORF names
      RJ639_016418

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • UCBG64.0493
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > asterids > campanulids > Escalloniales > Escalloniaceae > Escallonia

Accessions

  • Primary accession
    A0AA88VDJ2

Proteomes

Subcellular Location

Keywords

  • Cellular component

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain568-617GRF-type
Domain804-847RING-type

Sequence similarities

Belongs to the DNA repair enzymes AP/ExoA family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    890
  • Mass (Da)
    98,868
  • Last updated
    2024-03-27 v1
  • Checksum
    702B2925C0080655
MNEDCDLQRQQSEEPHFTVRFPPTITPFLGCRYHLLSAKQELRADVVWADGFESFFSCTRTVDRGRTGYSGVATFCRVKSAFSSNEVALPVDAEEGFTGLLENARGFGTRKDEFPNVAEGLEEFSREVLLKVDSEGRCIITDHGHFVSKLAVLFNIYGPRAECDDTERIQFKHTFFKILQRRWESLLHRGRRILVVGDLNIAPAAIDRCDAGSDFEKNEFRKWFRSLLVENGGSFFDVFRAKHPERREAYTCWPTNTGAEEFNFGTRIDHILIAGSCLHEVHNLEGHDFVTCHVAECNILTQFKRWKPGNTPRWKGGRSIKLEGSDHAPVCISLFEIPNIPQHSTPSFSTRYCPQVEGCQQTLVSMLMRRQSAAKVNTTGGSSSSDEKVVVQSCNQSVKSSVEAYKLSGKSLDQPRPTEDSASVTDECSQASFHDVSNKMLLNLGNNNTKQMRCVYPNKKARHSQSSQLSLTSFFQKTSKCTGGDHSSDAVISLNQADLSSSNHYSGIASMNDDESVILEKSDLNICASSQNLVEFDACQSSEKEKRSVALLEWQRIQQHMQSSIPLCKGHGESCVSRIVKKEGPNSGRRFYVCARAEGPASNPEANCGYFKWADLRSKRKGRQFSLLVPAVLNMKHFGKQADLGYADLVLGREVDLVSLSKRQLVEDAKLALDKQDLNCLAPIVFDIKHLVGNLDSCLVKQASRALSFLLDSPPSPPPLAQPPLEVHHGYSEERTLYISLGVLVKVALISFLLNSLFCCSRRQSPNGVARAVASNDTQVTAYDSSAPSPLSSASSRLVESESCSICLAEFERGELLRVLPRCKHMFHKDCIDQWLPSRSLHCPVCRDCAIERDVKSGESCSSNTGTPAANSSDLLVLTFASTVHMPAHL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAVXUP010001965
EMBL· GenBank· DDBJ
KAK3006640.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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