A0AA87FF77 · A0AA87FF77_9ENTE

Function

function

Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.
One-carbon metabolism; tetrahydrofolate interconversion.

Features

Showing features for binding site, site.

Type
IDPosition(s)Description
Binding site116(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Binding site120-122(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Site224Plays an important role in substrate specificity
Binding site240(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Binding site350-352(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionglycine hydroxymethyltransferase activity
Molecular Functionpyridoxal phosphate binding
Biological Processglycine biosynthetic process from serine
Biological Processtetrahydrofolate interconversion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Serine hydroxymethyltransferase
  • EC number
  • Short names
    SHMT
    ; Serine methylase

Gene names

    • Name
      glyA
    • ORF names
      HMPREF9478_02528

Organism names

Accessions

  • Primary accession
    A0AA87FF77

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue225N6-(pyridoxal phosphate)lysine

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-381Serine hydroxymethyltransferase-like

Sequence similarities

Belongs to the SHMT family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    411
  • Mass (Da)
    44,554
  • Last updated
    2024-03-27 v1
  • MD5 Checksum
    C27371F8CBA499D1C2F0FD78E857140C
MDYQTFDPDLWQAIEKEADRQQNNLELIASENIVSAGVRAAQGSILTNKYAEGYPGRRYYGGCEFVDVVENLAIDRAKELFGAAYANVQPHSGSQANTAAYLALIEPGDTVMGMDLSAGGHLTHGSPVNFSGKTYHFVSYGVDPATEVIDYNVVRILARKHQPKLIVAGASAYSRTIDFAKFREIADEVGAKLMVDMAHIAGLVAAGLHPNPVPYADITTSTTHKTLRGPRGGLILTNDEDLAKKINSAVFPGIQGGPLEHVVAAKAVAFKEALDEDFKSYSEQVIRNAQAMAKVFNQAPQARLVSGATDNHLLLIDVRGFELNGKEAEALLDQVNITVNKNSIPFETLSPFKTSGIRVGTPAITSRGFKEEDAVEVAKLIVKVLEHPEDTAVLEEAKAQVKELTDKYPLY

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ADLY01000041
EMBL· GenBank· DDBJ
EHG27318.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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