A0AA87FDW8 · A0AA87FDW8_9ENTE

Function

function

Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Co2+ (UniProtKB | Rhea| CHEBI:48828 )

Note: Binds 1 Mg2+ ion per subunit. Can also utilize other divalent metal cations, such as Ca2+, Mn2+ and Co2+.
thiamine diphosphate (UniProtKB | Rhea| CHEBI:58937 )

Note: Binds 1 thiamine pyrophosphate per subunit. During the reaction, the substrate forms a covalent intermediate with the cofactor.

Features

Showing features for binding site, site, active site.

Type
IDPosition(s)Description
Binding site28substrate
Site28Important for catalytic activity
Binding site69thiamine diphosphate (UniProtKB | ChEBI)
Binding site117-119thiamine diphosphate (UniProtKB | ChEBI)
Binding site159thiamine diphosphate (UniProtKB | ChEBI)
Binding site188thiamine diphosphate (UniProtKB | ChEBI)
Binding site263substrate
Binding site263thiamine diphosphate (UniProtKB | ChEBI)
Site263Important for catalytic activity
Binding site357substrate
Binding site384substrate
Active site411Proton donor
Binding site437thiamine diphosphate (UniProtKB | ChEBI)
Binding site461substrate
Binding site469substrate
Binding site473substrate
Binding site520substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionmetal ion binding
Molecular Functiontransketolase activity
Biological Processpentose-phosphate shunt

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Transketolase
  • EC number

Gene names

    • ORF names
      HMPREF9478_02903

Organism names

Accessions

  • Primary accession
    A0AA87FDW8

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain354-525Transketolase-like pyrimidine-binding

Sequence similarities

Belongs to the transketolase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    665
  • Mass (Da)
    71,561
  • Last updated
    2024-03-27 v1
  • MD5 Checksum
    C59A4218F6E3DFC57CF9E0C36FADC29B
MFDKIDQLGVNTLRTLSIEAVQKANSGHPGLPMGAAPMAYALWTKHLKVNPTTSRNWIDRDRFVLSAGHGSALLYSLLHVSGYQVTTEDLKNFRQWGSRTPGHPEVGHTDGVEATTGPLGQGIAMAVGMAMAEKHLAATYNRDEYNVIDHYTYALCGDGDLMEGVSQEAASMAGHMKLDKLIVLYDSNDISLDGPTSKAFTENVGARFEAYGWQHLLVKDGNDLEAISQAIEAAKAETEKPTLIEIKTVIGYGAPNQGTSAVHGAPLGAEGISAAKAIYGWEYPEFTVPEEVAARFKETMIDEGQKAEAEWNEKFAAYKAAYPELAAQFEQAVAGELPADWDAELPTYEVGSSQASRVSSKEMIQALSKAIPSLWGGSADLSGSNNTMVAAEKDFEPGQYEGRNIWFGVREFAMAAAMNGIQLHGGTRVYGGTFFVFVDYLRPAVRLSALQHAPVIYVLTHDSVAVGEDGPTHEPIEQLASVRCMPNVQVIRPADGNETRAAWKIALQTTNKPTVLVLSRQNLPLLAGTLSGVEENVAKGGYVLSKQTGETPEGILIATGSEVNLAVEAQAKLAEAGVDVSVVSLPSFDLFEAQSEEYKESVLPKAVKKRVAIEAASPFGWDRYLGCKGKVIAIDHFGASAPGNKVLEEFGFTVENVVATFQSIK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ADLY01000050
EMBL· GenBank· DDBJ
EHG26355.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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