A0AA85B6A9 · A0AA85B6A9_9TREM
- ProteinPhosphatidylserine synthase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids480 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.
Catalytic activity
- 1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-L-serine + ethanolamineThis reaction proceeds in the forward direction.
- 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + ethanolamineThis reaction proceeds in the forward direction.
- 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamineThis reaction proceeds in the forward direction.
- 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamineThis reaction proceeds in the forward direction.
- 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamineThis reaction proceeds in the forward direction.
- 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamineThis reaction proceeds in the forward direction.
- 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + L-serine = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoserine + ethanolamineThis reaction proceeds in the forward direction.
- 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamineThis reaction proceeds in the forward direction.
Pathway
Lipid metabolism.
Phospholipid metabolism; phosphatidylserine biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | L-serine-phosphatidylethanolamine phosphatidyltransferase activity | |
Biological Process | phosphatidylserine biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphatidylserine synthase
- EC number
- Alternative names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Spiralia > Lophotrochozoa > Platyhelminthes > Trematoda > Digenea > Strigeidida > Schistosomatoidea > Schistosomatidae > Schistosoma
Accessions
- Primary accessionA0AA85B6A9
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 58-80 | Helical | ||||
Sequence: FFWNTHTVLCLFIFACILIYVAL | ||||||
Transmembrane | 92-110 | Helical | ||||
Sequence: MKRGISAVIMVFVLFGVLH | ||||||
Transmembrane | 122-143 | Helical | ||||
Sequence: AFWRFILCLSILYELILVFLLF | ||||||
Transmembrane | 313-335 | Helical | ||||
Sequence: WLGTLVLAIAILTAELNTFYLKF | ||||||
Transmembrane | 341-361 | Helical | ||||
Sequence: PPHFLCLGRLIFLTLMGATAI | ||||||
Transmembrane | 381-399 | Helical | ||||
Sequence: WMISSIIITEFLIVMKFGW | ||||||
Transmembrane | 411-436 | Helical | ||||
Sequence: SIFWSLVLIGLVSWTFWHFYIVPWLF |
Keywords
- Cellular component
Structure
Family & Domains
Sequence similarities
Belongs to the phosphatidyl serine synthase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length480
- Mass (Da)57,263
- Last updated2024-03-27 v1
- ChecksumEB66BC3ABE7929D0