A0AA85B6A9 · A0AA85B6A9_9TREM

  • Protein
    Phosphatidylserine synthase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.

Catalytic activity

  • 1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine
    This reaction proceeds in the forward direction.
  • 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine
    This reaction proceeds in the forward direction.
  • 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine
    This reaction proceeds in the forward direction.
  • 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine
    This reaction proceeds in the forward direction.
  • 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + L-serine = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoserine + ethanolamine
    This reaction proceeds in the forward direction.
  • 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine
    This reaction proceeds in the forward direction.
  • a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine
    EC:2.7.8.29 (UniProtKB | ENZYME | Rhea)

Pathway

Lipid metabolism.
Phospholipid metabolism; phosphatidylserine biosynthesis.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular FunctionL-serine-phosphatidylethanolamine phosphatidyltransferase activity
Biological Processphosphatidylserine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphatidylserine synthase
  • EC number
  • Alternative names
    • Serine-exchange enzyme

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Spiralia > Lophotrochozoa > Platyhelminthes > Trematoda > Digenea > Strigeidida > Schistosomatoidea > Schistosomatidae > Schistosoma

Accessions

  • Primary accession
    A0AA85B6A9

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane58-80Helical
Transmembrane92-110Helical
Transmembrane122-143Helical
Transmembrane313-335Helical
Transmembrane341-361Helical
Transmembrane381-399Helical
Transmembrane411-436Helical

Keywords

Family & Domains

Sequence similarities

Belongs to the phosphatidyl serine synthase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    480
  • Mass (Da)
    57,263
  • Last updated
    2024-03-27 v1
  • Checksum
    EB66BC3ABE7929D0
MKKPCRSDDLREKYLERNNKQNNIQSTFMHSGHYQTAYNWEDEKNRTKDFYDDGTSTFFWNTHTVLCLFIFACILIYVALLENGNYSSEYNMKRGISAVIMVFVLFGVLHTPDGPFLRPHPAFWRFILCLSILYELILVFLLFQSVDDARQWLRYLDLELGKPLEEKDYGGNCRIYDWDRPDNPWHNVISKMDGFVTVHFVGWWAKTLILRDYWICNVLSFAFEVLEYSLEHQLPNFSECWWDHWIMDFLGCNLLGIWLGMKTINYLSMKPYHWRGMWNIPSYRGKLRRVMLQFTPRRWTDFDWRPTGSLKRWLGTLVLAIAILTAELNTFYLKFVLWVPPPHFLCLGRLIFLTLMGATAIREYFEYLDDPKCKRFGRQAWMISSIIITEFLIVMKFGWDIITKPFPSHISIFWSLVLIGLVSWTFWHFYIVPWLFRSSRVSKNGKPAEETIQNHRPQKVENPVVYRRSARSSVKLLNHS

Genome annotation databases

Similar Proteins

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