A0AA50KQV8 · A0AA50KQV8_9GAMM

  • Protein
    Multifunctional fusion protein
  • Gene
    cysN
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

APS kinase catalyzes the synthesis of activated sulfate.
Catalyzes the synthesis of activated sulfate.
With CysD forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.

Catalytic activity

Pathway

Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.
Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site31-38GTP (UniProtKB | ChEBI)
Binding site110-114GTP (UniProtKB | ChEBI)
Binding site165-168GTP (UniProtKB | ChEBI)
Binding site468-475ATP (UniProtKB | ChEBI)
Active site542Phosphoserine intermediate

GO annotations

AspectTerm
Molecular Functionadenylylsulfate kinase activity
Molecular FunctionATP binding
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Molecular Functionsulfate adenylyltransferase (ATP) activity
Biological Processsulfate assimilation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Multifunctional fusion protein

Including 2 domains:

  • Recommended name
    Sulfate adenylyltransferase subunit 1
  • EC number
  • Alternative names
    • ATP-sulfurylase large subunit
    • Sulfate adenylate transferase
      (SAT
      )
  • Recommended name
    Adenylyl-sulfate kinase
  • EC number
  • Alternative names
    • APS kinase
    • ATP adenosine-5'-phosphosulfate 3'-phosphotransferase
    • Adenosine-5'-phosphosulfate kinase

Gene names

    • Name
      cysN
    • Synonyms
      cysC
    • ORF names
      PU634_06690

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • NTOU-MSR1
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Aeromonadales > Aeromonadaceae > Oceanimonas

Accessions

  • Primary accession
    A0AA50KQV8

PTM/Processing

Keywords

Interaction

Subunit

Heterodimer composed of CysD, the smaller subunit, and CysN.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain22-243Tr-type G

Sequence similarities

Belongs to the APS kinase family.
In the C-terminal section; belongs to the APS kinase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    640
  • Mass (Da)
    71,138
  • Last updated
    2024-01-24 v1
  • Checksum
    74FDD41B1F629482
MAHQSDLIASDIEQYLQQHEHKSLLRFITCGSVDDGKSTLIGRLLFESKMLFEDQLAAMEADSKKYGTQGEDIDFALLVDGLAAEREQGITIDVAYRFFSTDKRKFIVADTPGHEQYTRNMVTGASTADAAILMVDARKGILTQTRRHSYLMSLLGIRQVVVAINKMDLVNYSEDTFRKIKEDYAQFAEQLNLDNITYIPMSAFKGDNIVEPSANMPWYHGTTLMGYLETVEVDDTRMQRAPFRLPVQWVNRPNLDFRGFAGTIASGVVKPGDRIRVLPSGKESTVDRIVVHGGDLPEAVAGQSVTLTLKDEIDISRGDVISTAEAPVETADQFESTLVWMHEDPLLPGRPYLLKIGTKTVTASVTDIKYQVNVNTLEHVAAKKLDLNGIAVCNLSLDRAIAFDDYQSNKDTGGFILIDRLSNNTVAAGMLHFSLRRSQNIHMQHVDVNKEARALSKGQKPAVLWFTGLSGAGKSTIANLVEKKLHAQGNHTYLLDGDNVRHGLNKDLGFTDADRVENIRRVAEVSKLMVDAGLIVLTAFISPFRAERRLARELLEDGEFIEVHVDTPLNVAEERDVKGLYKKARRGELKNFTGIDSAYEQPENPEIRLDTTRLSADEAADAVIELLKEKGIIGNGDWSI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP118224
EMBL· GenBank· DDBJ
WMC12044.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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