A0AA50HZT9 · A0AA50HZT9_9SYNC

  • Protein
    Epoxyqueuosine reductase
  • Gene
    queG
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 2 [4Fe-4S] clusters per monomer.
cob(II)alamin (UniProtKB | Rhea| CHEBI:16304 )

Pathway

tRNA modification; tRNA-queuosine biosynthesis.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site50cob(II)alamin (UniProtKB | ChEBI)
Active site123Proton donor
Binding site123cob(II)alamin (UniProtKB | ChEBI)
Binding site144cob(II)alamin (UniProtKB | ChEBI)
Binding site147cob(II)alamin (UniProtKB | ChEBI)
Binding site158cob(II)alamin (UniProtKB | ChEBI)
Binding site177[4Fe-4S] cluster 1 (UniProtKB | ChEBI)
Binding site180[4Fe-4S] cluster 1 (UniProtKB | ChEBI)
Binding site183[4Fe-4S] cluster 1 (UniProtKB | ChEBI)
Binding site187[4Fe-4S] cluster 2 (UniProtKB | ChEBI)
Binding site203[4Fe-4S] cluster 2 (UniProtKB | ChEBI)
Binding site231[4Fe-4S] cluster 2 (UniProtKB | ChEBI)
Binding site231-232cob(II)alamin (UniProtKB | ChEBI)
Binding site234[4Fe-4S] cluster 2 (UniProtKB | ChEBI)
Binding site238[4Fe-4S] cluster 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functioncobalamin binding
Molecular Functionepoxyqueuosine reductase activity
Molecular Functionmetal ion binding
Biological Processqueuosine biosynthetic process
Biological ProcesstRNA modification

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Epoxyqueuosine reductase
  • EC number
  • Alternative names
    • Queuosine biosynthesis protein QueG

Gene names

    • Name
      queG
    • ORF names
      NON20_12075

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • B12
  • Taxonomic lineage
    Bacteria > Cyanobacteriota > Cyanophyceae > Synechococcales > Merismopediaceae > Synechocystis

Accessions

  • Primary accession
    A0AA50HZT9

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain168-1974Fe-4S ferredoxin-type

Sequence similarities

Belongs to the QueG family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    301
  • Mass (Da)
    33,860
  • Last updated
    2024-01-24 v1
  • Checksum
    6F17DBE6E267C503
MKAQALAIGFHRVGIAPVSETENDEAAQRLQSWIALGYNADMAWMANPKRQNIRELLPSARSVIAVGLNYYTPHQRSGDPAHGKISRYAWGRDYHRVLTKKLKALNLWLEQQVPDLQSRYYVDTGPIQEKAWAERAGLGWVGKNGNLISRDYGSWLFLGEIVTNITLQGDRPHSQHCGTCTRCLESCPTQAIVEPFVVDSNKCIAYHTIENRAEILPTAIADNLQGWVAGCDICQDVCPWNQRFAQPTDVADFDPYEGNLNPELETLANITEADWQQQFTASALRRIKPAMLRRNAQANLQ

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP101709
EMBL· GenBank· DDBJ
WLT40060.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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