A0AA49Q3W6 · A0AA49Q3W6_9BACT
- Protein3-deoxy-D-manno-octulosonic acid transferase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids427 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.
Catalytic activity
- CMP-3-deoxy-beta-D-manno-octulosonate + lipid IVA (E. coli) = alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H+
Pathway
Bacterial outer membrane biogenesis; LPS core biosynthesis.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 68 | Proton acceptor | ||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | transferase activity | |
Biological Process | lipid A biosynthetic process | |
Biological Process | lipopolysaccharide core region biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name3-deoxy-D-manno-octulosonic acid transferase
- EC number
- Short namesKdo transferase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Gemmatimonadota > Gemmatimonadia > Gemmatimonadales > Gemmatimonadaceae
Accessions
- Primary accessionA0AA49Q3W6
Subcellular Location
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 48-217 | 3-deoxy-D-manno-octulosonic-acid transferase N-terminal | ||||
Sequence: ARIRRDPARPLVWIHAPSVGEGLQAKPVIQLLRERRPDVQLVYTHFSPSAEAMARGLDADLAAYLPFDRPHNAEVLLDALRPTALVYSKLDVWPMLTAAAARRGVRLGMVSATLSSRSGRSGPMARALLHDAYAALDAVGAIDPDDADRLVALGVRRERIRITGDTRYDQ |
Sequence similarities
Belongs to the glycosyltransferase group 1 family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length427
- Mass (Da)46,219
- Last updated2024-01-24 v1
- Checksum2BB120A797F0B0DF