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A0AA49JUE1 · A0AA49JUE1_9BACT

Function

function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 2 [4Fe-4S] clusters per subunit.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site69[4Fe-4S] cluster 1 (UniProtKB | ChEBI)
Binding site72[4Fe-4S] cluster 1 (UniProtKB | ChEBI)
Binding site75[4Fe-4S] cluster 1 (UniProtKB | ChEBI)
Binding site79[4Fe-4S] cluster 2 (UniProtKB | ChEBI)
Binding site108[4Fe-4S] cluster 2 (UniProtKB | ChEBI)
Binding site111[4Fe-4S] cluster 2 (UniProtKB | ChEBI)
Binding site114[4Fe-4S] cluster 2 (UniProtKB | ChEBI)
Binding site118[4Fe-4S] cluster 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functioniron ion binding
Molecular FunctionNADH:ubiquinone reductase (non-electrogenic) activity
Molecular Functionquinone binding
Biological Processaerobic respiration

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-quinone oxidoreductase subunit I
  • EC number
  • Alternative names
    • NADH dehydrogenase I subunit I
    • NDH-1 subunit I

Gene names

    • Name
      nuoI
    • ORF names
      Strain138_001499
      , Strain318_001499

Organism names

  • Taxonomic identifier
  • Strains
    • Strain 138
    • Strain 318
  • Taxonomic lineage
    Bacteria > Gemmatimonadota > Gemmatimonadia > Gemmatimonadales > Gemmatimonadaceae > Pseudogemmatithrix

Accessions

  • Primary accession
    A0AA49JUE1
  • Secondary accessions
    • A0AA49K039

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein

Keywords

PTM/Processing

Keywords

Interaction

Subunit

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain59-894Fe-4S ferredoxin-type
Domain99-1284Fe-4S ferredoxin-type

Sequence similarities

Belongs to the complex I 23 kDa subunit family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    165
  • Mass (Da)
    18,784
  • Last updated
    2024-01-24 v1
  • Checksum
    3D45875DBCBE6876
MAINVKVMERPVGEVSYVRATLSGLGLTLKHLVNPHKVTVQYPDERWDISPRWRGTHRMLTTEDGKAKCVACGLCPTVCPANCIKLVPGEDEAGNRYPLVFEIDEFRCIFCGYCQEVCPEEAIHMGRHYENAEYSRDKFVYDLERLTAQTHPVSELWDPADPRGE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP130612
EMBL· GenBank· DDBJ
WKW12217.1
EMBL· GenBank· DDBJ
Genomic DNA
CP130613
EMBL· GenBank· DDBJ
WKW15126.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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