A0AA49JTT1 · A0AA49JTT1_9BACT

Function

function

Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.

Catalytic activity

Pathway

Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 5/5.

Features

Showing features for binding site, active site, site.

124020406080100120140160180200220240
TypeIDPosition(s)Description
Binding site83-amino-2-oxopropyl phosphate (UniProtKB | ChEBI)
Binding site10-111-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site193-amino-2-oxopropyl phosphate (UniProtKB | ChEBI)
Active site44Proton acceptor
Binding site461-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site511-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Active site71Proton acceptor
Binding site1011-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Site152Transition state stabilizer
Active site189Proton donor
Binding site1903-amino-2-oxopropyl phosphate (UniProtKB | ChEBI)
Binding site211-2123-amino-2-oxopropyl phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionpyridoxine 5'-phosphate synthase activity
Biological Processpyridoxine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Pyridoxine 5'-phosphate synthase
  • EC number
  • Short names
    PNP synthase

Gene names

    • Name
      pdxJ
    • ORF names
      Strain138_001044

Organism names

Accessions

  • Primary accession
    A0AA49JTT1

Subcellular Location

Keywords

Interaction

Subunit

Homooctamer; tetramer of dimers.

Family & Domains

Sequence similarities

Belongs to the PNP synthase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    240
  • Mass (Da)
    26,059
  • Last updated
    2024-01-24 v1
  • Checksum
    1E9E234DE2BE9375
MYQRLYINIDHVATLRQARRASYPDPVAAARICEDAGADGITVHLREDRRHIQDADVEALATSLRTPMNLEMAATPEMTLIALRIKPKQVTLVPERRAEITTEGGLDLFADPTRLMTCLENLHAAGIRTSLFIDPDLRQIARAADLKVPAIELHTGRYCHHPEVPAHLAALRQAAVEAKGLGLAVHAGHGLTLENVGPVAAIPECEELNIGHAIVSHAVFVGLDAAVRAMRAAMDAARPR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP130612
EMBL· GenBank· DDBJ
WKW11780.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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