A0AA49JTG3 · A0AA49JTG3_9BACT

Function

function

This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

  • Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.
    EC:3.4.23.36 (UniProtKB | ENZYME | Rhea)

Pathway

Protein modification; lipoprotein biosynthesis (signal peptide cleavage).

Features

Showing features for active site.

118320406080100120140160180
TypeIDPosition(s)Description
Active site130
Active site148

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionaspartic-type endopeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lipoprotein signal peptidase
  • EC number
  • Alternative names
    • Prolipoprotein signal peptidase
    • Signal peptidase II
      (SPase II
      )

Gene names

    • Name
      lspA
    • ORF names
      Strain138_000855

Organism names

Accessions

  • Primary accession
    A0AA49JTG3

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane76-93Helical
Transmembrane100-119Helical
Transmembrane139-163Helical

Keywords

Family & Domains

Sequence similarities

Belongs to the peptidase A8 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    183
  • Mass (Da)
    19,798
  • Last updated
    2024-01-24 v1
  • Checksum
    ECB74E3BA71BDA1D
MSVTPHSFFPLASPRNHAFATPFAVVLVLDVVTKRWAEATLALHTPVEVVGAALRWTLTYNTGAAMSLSVGESSRAFFSIVAIGMVAYLLMLLRQAPAQARAVPAALGMLAAGAIGNLIDRLRHDRGVVDFIDVGTASWRFWTFNVADIGVSCGAILLALLLWREDRVAHKLQMSQSPESPDR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP130612
EMBL· GenBank· DDBJ
WKW11600.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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