A0AA49IH20 · A0AA49IH20_9RHAB

  • Protein
    RNA-directed RNA polymerase L
  • Gene
    L
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

Catalytic activity

  • GTP + H2O = GDP + phosphate + H+
  • a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine = a 5'-end (N7-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-homocysteine
  • a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + 2 S-adenosyl-L-methionine = a 5'-end (N7-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + 2 S-adenosyl-L-homocysteine + H+
    EC:2.1.1.375 (UniProtKB | ENZYME | Rhea)
  • a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine = a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-homocysteine + H+
  • a 5'-end triphospho-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + GDP + H+ = a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + diphosphate
    EC:2.7.7.88 (UniProtKB | ENZYME | Rhea)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componenthost cell cytoplasm
Cellular Componentvirion component
Molecular FunctionATP binding
Molecular Functionhydrolase activity
Molecular FunctionmRNA 5'-cap (guanine-N7-)-methyltransferase activity
Molecular FunctionRNA-dependent RNA polymerase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    RNA-directed RNA polymerase L
  • EC number
  • Alternative names
    • Large structural protein
    • Replicase
    • Transcriptase

Gene names

    • Name
      L

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • ISR-1655/1/22
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Negarnaviricota > Haploviricotina > Monjiviricetes > Mononegavirales > Rhabdoviridae > Alpharhabdovirinae > Ephemerovirus

Accessions

  • Primary accession
    A0AA49IH20

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain620-806RdRp catalytic
Domain1676-1873Mononegavirus-type SAM-dependent 2'-O-MTase

Sequence similarities

Belongs to the rhabdoviridae protein L family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,138
  • Mass (Da)
    247,322
  • Last updated
    2024-01-24 v1
  • MD5 Checksum
    DB8CB420B6E8605349A3D48580C99D16
MDSFEEFDSNLGFDDLDTLDQDNDYSQAEVDEIIESMDLINNKDYNLNSPLIPDDLRDLIQFIKEDGRNPNNLDESVYIQEEIVVIKRVLKNIVKLAYIPQVEDLHMKFSEFLNVIELNPIYWQSGEVLENLIAGLHEIPAAFFRGIGLDETLVVNEVQRKWNDVPNRAKSWFLKFLDLHKVTCLMNARSNIEIENIKRKEKTVDINTSSLGLRTSQRSILIEFETSGRWVIFNNNCYSMKYNMMINREFLLMIKDVLISRFQTILSLIICQDEYPYTEAEIERVMQLYWEGDDLLRTHGNKAYKGIKLIESMCNLRIINIVSKSRPLIPKFPNFENHIYRSIDELQKERGLDLTKMADIILNEDSIDMTLVYYSSFRHWGHPWIDYLTGLKKLEEQVNKQCDVDVDYANRLASDLAYKVLRKTFLEKKVWAVEKNQMDTKSKLYNHIKYNTWPTQQTIDEFGDNWHRLPLKKCYDVPDMIDISLLYSDKSHSLDRSEVIKIVREGKHKRIPTKRVLQTLLERKATNWPEFLKEVNDRGLDWEKLVIGLKAKERELKEEGRFFSMMSFELRDYFVSTEYLIKKYYVPLFEGLTMADDLNTVIKKMLEVSSGQGSRDYQYITIANNIDYEKWNNYQRIESNGPVFRVMGQFLGLPELFVRTHEFFQKSLIYYNHRADLMLARGDQLINKTGALVCWEGQRGGLEGLRQKGWSILNYLMIERESRIRNTRVKILAQGDNQTISMHYKTESWHDEEELKNHISRMVENNNQIMGAIIEGTKRLGLRINHDETMTSPDYINYGKVPIIEGTIRGLPTKRWSRVNFTSNDQLPSTSTILNSSSTNALTVCHFSERPIDAINGHMVLGSIGLMLLNYHNPALRGQTDRFIKEATLNNQNYNRLLMYLDPSLGGIGGTSLTRFFIRSFPDGVTESLSFWKIVHDNTGDENLRKLCVTIGEPELNNLKPEDLDKLVEKPESLNIKHGLSSSNLLKGEVKKNLIQNCARIENEIVRDAAKNMICEETQLYLWLRNIKPLFPRFLSQFAESTYFGVTKSLINLFTNSKTVRGIYKKKYNKELDSLVIESEIKSLQSLIRTIKKADSQMQTIWTCSAAKADHLRRKSWGTDVLGTTVPHPSEMFLGEKGGEDQCKICFGNEKSNSYLTILTPKGVPTKCEYRGPYHPYLGSTTKESTSILQPWEKETKVPVLRRACDLRKCINWFVEPDSNVAKSIFNNLKALTGEDWEDQIKGYKRTGSSLHRFTCSRVSAGGYAGSAPSAISWCISTTDTMCGLGDKNFDFMFQSTILWCQMITIIKERGSNSAKIYHYHINCPDCLREIKEPTLEADWEYEPRDVSQILEKWRPASMEKWGEEKIHLEIQDNDSDWDRLDELDKSYEVGKTIGWLTADSILNQKREIDYGALYPISIRGKLAGGPFFSGMLDGYKLCSSLNLTHRRNYMILKKPKLAVQGTVFFLIDRCSFITELTNFVSHPNLYHVLKSIPHKVPTSYPMNLADVGSIVRGYLKYLFYSMGDKVHSEVSWVFSDMRTNELIISYGLSHITHRVMLSKRGIKEIKMELQQCQDLYIQIMNNEEQDLGEQNRRREIVECLKNLKFVSSEIRHAVKFGLVTLSTENQANDRPADWGKEYTSDIYSLEPWFLSCNETKEVIKLNIPYISNPLISGLRVNQIATGAHYKIRALVERENILYNDFLCGGDGSGGMTSCLLRLNPGSRGIFNSLLMLDDKPLHGTKPSPPTAILELGTHSNRCVNLYEVWKEPSDLAKRETWIYFEKCRRKTNLRINLIVLDMECISNDILYNIHKELLSFLPKNLEEGGTVIIKTYLSHLLSEDLCVVEKLAHLFDSTKICNTMISSTNTSEVYIVFKGYRHGFKVMRKLDRQHIVNNKEFFFVFRTMEEEFQRAKALSKEDLGMGVPQSLSPDSVIELSQLLHCAGVDGVSIATLCQPENMTFFSTFEFGCILLCIISESHIRTTKIHKPPCGCKDENILSDQSIKIWLASIGGIGLRMSLDLDDSSIYKAIHNWINSRGEKEINVVLDKSSTLKWEIKDKRRNLIKPLWNKQFGLSDKMALMGNWIRWYERCKRKNDKADKKEGKINNFLQFVNKGLTIEHARNHYDQEIQKLFKFWKE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
OQ679991
EMBL· GenBank· DDBJ
WGO62847.1
EMBL· GenBank· DDBJ
Viral cRNA

Similar Proteins

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