A0AA49FLT6 · A0AA49FLT6_9PROT

Function

function

Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.

Catalytic activity

Pathway

Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 5/5.

Features

Showing features for binding site, active site, site.

125120406080100120140160180200220240
Type
IDPosition(s)Description
Binding site73-amino-2-oxopropyl phosphate (UniProtKB | ChEBI)
Binding site9-101-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site183-amino-2-oxopropyl phosphate (UniProtKB | ChEBI)
Active site43Proton acceptor
Binding site451-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site501-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Active site70Proton acceptor
Binding site1001-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Site151Transition state stabilizer
Active site198Proton donor
Binding site1993-amino-2-oxopropyl phosphate (UniProtKB | ChEBI)
Binding site220-2213-amino-2-oxopropyl phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionpyridoxine 5'-phosphate synthase activity
Biological Processpyridoxine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Pyridoxine 5'-phosphate synthase
  • EC number
  • Short names
    PNP synthase

Gene names

    • Name
      pdxJ
    • ORF names
      OHM77_03265

Organism names

Accessions

  • Primary accession
    A0AA49FLT6

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homooctamer; tetramer of dimers.

Family & Domains

Sequence similarities

Belongs to the PNP synthase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    251
  • Mass (Da)
    27,257
  • Last updated
    2024-01-24 v1
  • MD5 Checksum
    60E65A90391DB4A3C1F474D2D39D5A1C
MIELGVNIDHVATIRQARRTYEPDPVWAAVEAHLGGADGITVHLREDRRHIQDQDVRRLRELTHIKLNLEMAATGEMVGIACGLKPEMAMLVPEGRHEITTEGGLDVAGQEAKLKDAVAKLADAGIVTSVFVDAELAQLEAAARIGAKVCEIHTGPYAHAFHGRGRDAESPAVVAELEKIRAAGQAIRDLGMRFNAGHALNYFNVQPVARLPGVRELHIGHAIVSRAVFVGMREAVREMKRLMREAAGAQS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP107246
EMBL· GenBank· DDBJ
WIM06321.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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