A0AA45P848 · A0AA45P848_BIFLN

  • Protein
    Diaminopimelate decarboxylase
  • Gene
    lysA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site332pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site374-377pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site377substrate
Binding site426substrate
Binding site430substrate
Binding site458substrate
Binding site487pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site487substrate

GO annotations

AspectTerm
Molecular Functiondiaminopimelate decarboxylase activity
Molecular Functionpyridoxal phosphate binding
Biological Processlysine biosynthetic process via diaminopimelate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Diaminopimelate decarboxylase
  • EC number
  • Short names
    DAP decarboxylase
    ; DAPDC

Gene names

    • Name
      lysA
    • ORF names
      B5U78_10190

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • ICIS-505
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Bifidobacteriales > Bifidobacteriaceae > Bifidobacterium

Accessions

  • Primary accession
    A0AA45P848

Proteomes

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue72N6-(pyridoxal phosphate)lysine

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain54-188Orn/DAP/Arg decarboxylase 2 N-terminal
Domain277-381Orn/DAP/Arg decarboxylase 2 N-terminal
Domain382-485Orn/DAP/Arg decarboxylase 2 C-terminal

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    530
  • Mass (Da)
    56,670
  • Last updated
    2024-01-24 v1
  • Checksum
    130ABC4846A9FDD9
MPISPIWPAATAVNAEGSIEFHGRTAESLLDEFGSPLYLIDTDEVVACARHFVRAAAEAFNTSTTHVSFAGKAFLSKEVVRLVTEAGMFVDTCTMGEMKIALAAGVPGRRLVLHGNNKSDEEIALAIEQGFAKIVIDEPDEPERVAAIARKLGKRARVMLRVTVGVHAGGHEYISTAHEDQKFGVPLLAAGADAAVLDVLNDLKDVTPAATNARISATHSLENGAEKTEKSERELHYDVKYPYDLSHEEVSDTDKALAAAMEAIADGPSIAVLKTILANQDVLELVGAHSHIGSNIHDADAFIHAAKRMMLLRKTLWATDAYILPEIDLGGGYSVAYTDGEDSMDIDVELTRLADAVNSTNRALGMPAPAISFEPGRYIVAPAGVTLYRVGTIKHVHLSDAKDSDGNPIAERVYVSVDGGMSDNIRPALYGADYTARLANRTGSAETMLARVCGMHCESGDIVVHEVQLPADLKRGDILAVPVTGAYGRTMASNYNQALIPAVVAVSESGAHVMLRRQTVDDLLNLDVSE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
RJZF01000011
EMBL· GenBank· DDBJ
ROV51382.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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