A0AA44CQ00 · A0AA44CQ00_YERMO

  • Protein
    Deoxyuridine 5'-triphosphate nucleotidohydrolase
  • Gene
    dut
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site71-73substrate
Binding site84substrate
Binding site88-90substrate

GO annotations

AspectTerm
Molecular FunctiondUTP diphosphatase activity
Molecular Functionmagnesium ion binding
Biological ProcessdUMP biosynthetic process
Biological ProcessdUTP catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Deoxyuridine 5'-triphosphate nucleotidohydrolase
  • EC number
  • Short names
    dUTPase
  • Alternative names
    • dUTP pyrophosphatase

Gene names

    • Name
      dut
    • ORF names
      HB991_20110

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • SCPM-O-B-7610
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Yersiniaceae > Yersinia

Accessions

  • Primary accession
    A0AA44CQ00

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain17-150dUTPase-like

Sequence similarities

Belongs to the dUTPase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    152
  • Mass (Da)
    16,346
  • Last updated
    2024-01-24 v1
  • MD5 Checksum
    81A5F8EA8A6F87B856EA2AE07825DD3D
MMKKIDIKILDPRVGNEFPLPTYATEGSAGLDLRACLDEAVDLLPGQTTLLPTGLAIHIGDNALAAVILPRSGLGHKHGVVLGNLVGLIDSDYQGQLMVSVWNRGQQPFTIEPGERIAQMVFVPVVQAEFNLVEDFDLTERGTGGFGHSGRQ

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAASAI010000033
EMBL· GenBank· DDBJ
NIL24803.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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