A0AA43T5U2 · A0AA43T5U2_9BIFI

Function

function

Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N2-acetylornithine and glutamate.

Miscellaneous

Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N2-acetyl-L-ornithine (cyclic): step 1/1.
Amino-acid biosynthesis; L-arginine biosynthesis; N2-acetyl-L-ornithine from L-glutamate: step 1/4.

Features

Showing features for site, binding site, active site.

TypeIDPosition(s)Description
Site110Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Site111Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Binding site149substrate
Binding site172substrate
Site182-183Cleavage; by autolysis
Active site183Nucleophile
Binding site183substrate
Binding site263substrate
Binding site385substrate
Binding site390substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionglutamate N-acetyltransferase activity
Molecular FunctionL-glutamate N-acetyltransferase activity
Biological Processarginine biosynthetic process
Biological Processornithine biosynthetic process

Keywords

Names & Taxonomy

Protein names

Including 2 domains:

  • Recommended name
    Glutamate N-acetyltransferase
  • EC number
  • Alternative names
    • Ornithine acetyltransferase
      (OATase
      )
    • Ornithine transacetylase
  • Recommended name
    Amino-acid acetyltransferase
  • EC number
  • Alternative names
    • N-acetylglutamate synthase
      (AGSase
      )

Gene names

    • Name
      argJ
    • ORF names
      OB936_06650
      , OB951_07510

Organism names

Accessions

  • Primary accession
    A0AA43T5U2

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_50426371281-182Arginine biosynthesis bifunctional protein ArgJ alpha chain
ChainPRO_5042637129183-390Arginine biosynthesis bifunctional protein ArgJ beta chain

Keywords

Interaction

Subunit

Heterotetramer of two alpha and two beta chains.

Family & Domains

Sequence similarities

Belongs to the ArgJ family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    390
  • Mass (Da)
    39,955
  • Last updated
    2024-01-24 v1
  • Checksum
    E14D1747C75343F9
MSVTFAQGFSAAGVEAGISAVEGKKDLALVVNNGPLDAAAGVFTSNRFCAAPVQWTRKIVADGHVKAVILNSGGANACTGQPGYEQSKATAQKVAALVGAKDSDVAVCSTGLIGELLPLDHVLSGADKAFAALADTAQAGADASHAIMTTDTKPKTVELEGSNGFRIGGMVKGSGMIAPQLATMLCVITTDAVVSAGQLQAALNTGVEMSFNRIDVDGCMSTNDTVLLLASGASGIEPDPDEFNELVAQVTASLARQIVGDGEGASHDIRVKVTGATTEDAALACGRAVASSNLLKCAISGNDPNWGRIVSSLGTVPSEVAPYDSNKVTVDVNGVRICENGGAGRDRSEVDMTPREVHIDIDLHAGNAEATVWTDDLTHEYVHINADYES

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAOPMH010000008
EMBL· GenBank· DDBJ
MDH7890436.1
EMBL· GenBank· DDBJ
Genomic DNA
JAOPMD010000015
EMBL· GenBank· DDBJ
MDH7899879.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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