A0AA43T522 · A0AA43T522_9BIFI
- ProteinUvrABC system protein A
- GeneuvrA
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids995 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | excinuclease repair complex | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | DNA binding | |
Molecular Function | excinuclease ABC activity | |
Molecular Function | zinc ion binding | |
Biological Process | nucleotide-excision repair | |
Biological Process | SOS response |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameUvrABC system protein A
- Short namesUvrA protein
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Bifidobacteriales > Bifidobacteriaceae > Bifidobacterium
Accessions
- Primary accessionA0AA43T522
Proteomes
Subcellular Location
Interaction
Subunit
Forms a heterotetramer with UvrB during the search for lesions.
Structure
Family & Domains
Features
Showing features for domain, zinc finger.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 663-992 | ABC transporter | ||||
Sequence: VRKTKQLRVVGARENNLKGLTVNFPLGVFTCVTGVSGSGKSTLINQILYPVLADNLNGARIVPGKHTRVEGVDQCDKVIHVDQNPIGRTPRSNPATYTGVWDKIRTLFAKTPEAQVRGYGPGRFSFNVKGGRCEACHGDGTLKIEMNFLPDVYVDCEECHGKRYNRETLEVKYNGKSVADVLDMPIEEAAQFFKAYPSISRYLDTLVQVGLGYIRLGQPAPTLSGGESQRVKLATELQRRSTGKTVYILDEPTTGLHFEDVRKLLLVLQGLVDKGNTVIVIEHNLDVVKSADWLIDLGPEGGDGGGTIVTEGTPEQVAQCERSWTGKFLR | ||||||
Zinc finger | 795-821 | C4-type | ||||
Sequence: CEACHGDGTLKIEMNFLPDVYVDCEEC |
Sequence similarities
Belongs to the ABC transporter superfamily. UvrA family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length995
- Mass (Da)110,404
- Last updated2024-01-24 v1
- Checksum02D4AFE9EF4DD8A4
Keywords
- Technical term