A0AA43QYQ0 · A0AA43QYQ0_MYCAR

Function

function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

One-carbon metabolism; tetrahydrofolate interconversion.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site164-166NADP+ (UniProtKB | ChEBI)
Binding site228NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionmethenyltetrahydrofolate cyclohydrolase activity
Molecular Functionmethylenetetrahydrofolate dehydrogenase (NADP+) activity
Biological ProcessL-histidine biosynthetic process
Biological Processmethionine biosynthetic process
Biological Processpurine nucleotide biosynthetic process
Biological Processtetrahydrofolate interconversion

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional protein FolD

Including 2 domains:

  • Recommended name
    Methylenetetrahydrofolate dehydrogenase
  • EC number
  • Recommended name
    Methenyltetrahydrofolate cyclohydrolase
  • EC number

Gene names

    • Name
      folD
    • ORF names
      DCBHLPFO_00239

Organism names

Accessions

  • Primary accession
    A0AA43QYQ0

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-118Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Domain128-275Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding

Sequence similarities

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    290
  • Mass (Da)
    32,518
  • Last updated
    2024-01-24 v1
  • Checksum
    9D19397242EE7DD0
MYKLLDGRKTKEEIQEKIKNELKTLADSQLPILGILQVGNLEESNIYIKHKLNIAHSLGLKTNFIKLEENATEKTIKEAIKKLNEETTGFIIQLPIQTNNVKNINDLLNEIKIEKDIDGLNEVNQKSNFVLNKKSFLPATALGIIILLKKYNIDFESMNIGVVGQSKIVGKPLSDFFEQSNARVRRYDINTSKDDIYKNDLIVVSTGSRGCLNDVKLKDNVILVDVGIHRIENKIVGDIEVDKIKESVSYLTPVPGGVGPMTIVGLILNLIKAFDIQNGTNIFSKIINEF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAPFAR010000086
EMBL· GenBank· DDBJ
MDI3349661.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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