A0AA43QKY2 · A0AA43QKY2_9LECA

  • Protein
    3-hydroxyanthranilate 3,4-dioxygenase
  • Gene
    BNA1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Fe2+ (UniProtKB | Rhea| CHEBI:29033 )

Pathway

Cofactor biosynthesis; NAD+ biosynthesis; quinolinate from L-kynurenine: step 3/3.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site44O2 (UniProtKB | ChEBI)
Binding site48Fe cation (UniProtKB | ChEBI); catalytic
Binding site54Fe cation (UniProtKB | ChEBI); catalytic
Binding site54substrate
Binding site92Fe cation (UniProtKB | ChEBI); catalytic
Binding site96substrate
Binding site106substrate
Binding site121a divalent metal cation (UniProtKB | ChEBI)
Binding site124a divalent metal cation (UniProtKB | ChEBI)
Binding site158a divalent metal cation (UniProtKB | ChEBI)
Binding site161a divalent metal cation (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function3-hydroxyanthranilate 3,4-dioxygenase activity
Molecular Functionferrous iron binding
Biological Process'de novo' NAD biosynthetic process from tryptophan
Biological Processanthranilate metabolic process
Biological Processquinolinate biosynthetic process
Biological Processtryptophan catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    3-hydroxyanthranilate 3,4-dioxygenase
  • EC number
  • Alternative names
    • 3-hydroxyanthranilate oxygenase
      (3-HAO
      )
    • 3-hydroxyanthranilic acid dioxygenase
      (HAD
      )
    • Biosynthesis of nicotinic acid protein 1

Gene names

    • Name
      BNA1
    • ORF names
      OHK93_007666

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • LIQ254RAFAR
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Lecanoromycetes > OSLEUM clade > Lecanoromycetidae > Lecanorales > Lecanorineae > Ramalinaceae > Ramalina

Accessions

  • Primary accession
    A0AA43QKY2

Proteomes

Subcellular Location

Keywords

Family & Domains

Sequence similarities

Belongs to the 3-HAO family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    175
  • Mass (Da)
    20,044
  • Last updated
    2024-01-24 v1
  • Checksum
    FEDFDFFB83FBC6F6
MLSTPLNLPKWLEENSHLLKPPINNYCVYNEDVTVMIVGGPNARSDYHINETAEWFYQYRGSMLLKVVDDGHFRDIPIREGEMFLLPPNTPHNPVRFADTVGIVLEQPRPSQSKDRLRWYCQNCGKVVNEEAFHCTDLGTQIKEAVNQFKASDEKRKCEGCGELADLVPRNVVQP

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAPUFD010000007
EMBL· GenBank· DDBJ
MDI1488391.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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