A0AA43P850 · A0AA43P850_9BIFI

Function

function

Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for binding site.

1911100200300400500600700800900
TypeIDPosition(s)Description
Binding site603ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionaminoacyl-tRNA editing activity
Molecular FunctionATP binding
Molecular Functionvaline-tRNA ligase activity
Biological Processvalyl-tRNA aminoacylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Valine--tRNA ligase
  • EC number
  • Alternative names
    • Valyl-tRNA synthetase
      (ValRS
      )

Gene names

    • Name
      valS
    • ORF names
      OB951_09970

Organism names

Accessions

  • Primary accession
    A0AA43P850

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain, motif, region.

TypeIDPosition(s)Description
Domain31-114Aminoacyl-tRNA synthetase class Ia
Motif58-68'HIGH' region
Domain138-635Aminoacyl-tRNA synthetase class Ia
Motif600-604'KMSKS' region
Domain690-846Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Region876-911Disordered

Domain

ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    911
  • Mass (Da)
    102,240
  • Last updated
    2024-01-24 v1
  • Checksum
    60E2AAAA5DF9A35A
MTESQDNTINANLTPLPDKVGVDGLEDKWRGVWDENEVYKFQGTRDRKAVYSIDTPPPTVSGHLHVGHVFSYTHTDVIARFKRMNGYDVFYPMGWDDNGLPTERRVQNYYGVRVDTSLKYDPNFVPPFEGTDGKKIDAKDQVPISRKNFIELCEKLTAQDEKQFEALWRSLGLSIDWTQTYHTIGEHPQRVAQKAFLRNLARGEAYQKDAPGLWDVTFQTAVAQAELESREYPGFYHKVAFRLEDGTPIYIETTRPELLAACGALIAHPDDERYKQYFGQYVYSPLFHVKVPILAHKAAEMDKGAGIAMCCTFGDVTDVEWWRDLNLPLRSIIQRNGRIVMDTPDWIEDEEGKRVFQETAGKTTFSARKVIVDALRESGDLDGEPTPTKRMTNFYEKGDKPLEIVTSRQWYLKNGGTDQQLNAELIERGRELNFHPDFMRVRYENWVNGLNGDWLISRQRFFGVPFPLWYPVNEDGTADYDHPIVPSEDRLPIDPTDDVPEGYSEDQRDVPGGFTAEPDIMDTWATSSLTPQIVTRWEEPGEENQAIFNATFPMDLRPQGQDIIRTWLFSTVDRAHLENKCLPWANATLSGWILDPDHKKMSKSKGNVVVPDKPIKQFGADAVRYWAAAARLGLDATYDEGQMKIGRRLAIKLLNATKFALAIGREDENHHVGAPATANWNPADVTEPLDRAAMAKMALVVREATESLNNYEHSKALEVIENYFWQFCDDYIELVKNRAYGTADATGRVPSEKAVKSARTALGLGLDAFARLLAPYLPYATEEVWSWMHEGEGSVHHAAWPKAETYDAAAAAVSPELLTHAGEALAALRGIKSKAKVSMKTPILSVQLGVSDEARKSIESALDDIAEAGRVTGPISFTSPAAAAEGEDEAATDVTIAKSELGEPPAKKPKK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAOPMH010000014
EMBL· GenBank· DDBJ
MDH7890911.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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