A0AA42GU47 · A0AA42GU47_9HYPH
- ProteinATP-dependent Clp protease proteolytic subunit
- GeneclpP
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids209 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
Catalytic activity
- Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 106 | |||||
Sequence: S | ||||||
Active site | 106 | Nucleophile | ||||
Sequence: S | ||||||
Active site | 131 | |||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | endopeptidase Clp complex | |
Molecular Function | ATP-dependent peptidase activity | |
Molecular Function | ATPase binding | |
Molecular Function | serine-type endopeptidase activity | |
Biological Process | protein quality control for misfolded or incompletely synthesized proteins |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP-dependent Clp protease proteolytic subunit
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Brucellaceae > Brucella/Ochrobactrum group > Brucella
Accessions
- Primary accessionA0AA42GU47
Proteomes
Subcellular Location
Interaction
Subunit
Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.
Structure
Sequence
- Sequence statusComplete
- Length209
- Mass (Da)23,429
- Last updated2024-01-24 v1
- Checksum381CAF9130400737
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JAODYY010000001 EMBL· GenBank· DDBJ | MDH0123046.1 EMBL· GenBank· DDBJ | Genomic DNA |