A0AA38YBD2 · A0AA38YBD2_9EURO

  • Protein
    Nuclear distribution protein PAC1
  • Gene
    LIS1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentmicrotubule
Cellular Componentmicrotubule associated complex
Cellular Componentspindle pole
Molecular Functiondynein complex binding
Biological Processcell division
Biological Processestablishment of mitotic spindle orientation
Biological Processmicrotubule sliding

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Nuclear distribution protein PAC1
  • Alternative names
    • Lissencephaly-1 homolog
      (LIS-1
      )
    • nudF homolog

Gene names

    • Name
      LIS1
    • Synonyms
      PAC1
    • ORF names
      H2204_002369

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • TK_35
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Chaetothyriomycetidae > Chaetothyriales > Trichomeriaceae > Knufia

Accessions

  • Primary accession
    A0AA38YBD2

Proteomes

Subcellular Location

Cytoplasm, cytoskeleton
Note: Localizes to the plus ends of microtubules at the hyphal tip and the mitotic spindle poles.

Keywords

Interaction

Subunit

Self-associates. Interacts with NDL1 and dynein.

Family & Domains

Features

Showing features for repeat, region, compositional bias.

Type
IDPosition(s)Description
Repeat110-151WD
Repeat152-186WD
Repeat197-246WD
Repeat247-288WD
Repeat325-342WD
Repeat351-385WD
Region412-431Disordered
Compositional bias415-427Polar residues

Domain

Dimerization mediated by the LisH domain may be required to activate dynein.

Sequence similarities

Belongs to the WD repeat LIS1/nudF family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    457
  • Mass (Da)
    50,084
  • Last updated
    2024-01-24 v1
  • MD5 Checksum
    0130C9F670BCEC3744FEF519F68D1078
MSQLLTARQAEELHKSMVAYLISVGMNDSAVALRRESNLPDSFDDATAKKYETLLEKKWTSVVRLQKKIMDLEAKNTALQHEIDTATPLSSNRKIDPVTWLPRSPARHTLQGHRLPVTSVAFHPIFSSLASASEDSTIKIWDWELGELERTLKGHTKAVLDVDFGGPRGGTLLASCSSDLTIRLWDPSDEYKNIRTLPGHDHSISCIRFIPSGAAGAPLSGNTLVSASRDKTLRIWDVTTGYCLKTLKGHTDWVRAVTPSIDGRFLLSAGNDQIPRLWDANSGEVKITFLGHEHVVECVAFAPSTSYVHLSGIAGYKKPPPVGSSGEFLATGGRDKIIKIWDNRGTCHKTLVGHDNWVRGLVFHPGGRYLLSISDDKTIRCWDLSQECKCVKVVDESHQHFISSIRWAPDVPGQPMTNGDSNGVSTTTKKEDGVGGGKIRCVVATASVDLNVRVFAG

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias415-427Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAPDRN010000009
EMBL· GenBank· DDBJ
KAJ9642721.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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