A0AA38XLZ9 · A0AA38XLZ9_9EURO
- ProteinArginine-requiring protein 2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1182 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Bifunctional aspartate kinase and homoserine dehydrogenase that catalyzes the first and the third steps toward the synthesis of lysine, methionine and threonine from aspartate.
Catalytic activity
- L-aspartate + ATP = 4-phospho-L-aspartate + ADPThis reaction proceeds in the forward direction.
Cofactor
Pathway
Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.
Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.
Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | aspartate kinase activity | |
Molecular Function | ATP binding | |
Molecular Function | homoserine dehydrogenase activity | |
Molecular Function | homoserine kinase activity | |
Molecular Function | metal ion binding | |
Molecular Function | NADP binding | |
Biological Process | homoserine biosynthetic process | |
Biological Process | lysine biosynthetic process | |
Biological Process | methionine biosynthetic process | |
Biological Process | sterol biosynthetic process | |
Biological Process | threonine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameArginine-requiring protein 2
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Chaetothyriomycetidae > Chaetothyriales > Trichomeriaceae > Knufia
Accessions
- Primary accessionA0AA38XLZ9
Proteomes
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 472-546 | ACT | |||
Sequence similarities
In the C-terminal section; belongs to the homoserine dehydrogenase family.
In the N-terminal section; belongs to the aspartokinase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,182
- Mass (Da)122,849
- Last updated2024-01-24 v1
- MD5 Checksum54B35FEAB76D300E4835875E86BA519A
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JAPDRN010000177 EMBL· GenBank· DDBJ | KAJ9615949.1 EMBL· GenBank· DDBJ | Genomic DNA |