A0AA37X0M7 · A0AA37X0M7_9RHOB

Function

function

Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

biotin (UniProtKB | Rhea| CHEBI:57586 )

Pathway

Carbohydrate biosynthesis; gluconeogenesis.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site119ATP (UniProtKB | ChEBI)
Binding site203ATP (UniProtKB | ChEBI)
Active site296
Binding site542Mn2+ (UniProtKB | ChEBI)
Binding site614substrate
Binding site711Mn2+ (UniProtKB | ChEBI); via carbamate group
Binding site740Mn2+ (UniProtKB | ChEBI)
Binding site742Mn2+ (UniProtKB | ChEBI)
Binding site875substrate

GO annotations

AspectTerm
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionpyruvate carboxylase activity
Biological Processgluconeogenesis
Biological Processpyruvate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Pyruvate carboxylase
  • EC number

Gene names

    • Name
      pycA
    • ORF names
      GCM10010873_19030

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • NBRC 111766
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Rhodobacterales > Paracoccaceae > Cypionkella

Accessions

  • Primary accession
    A0AA37X0M7

Proteomes

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue711N6-carboxylysine
Modified residue1112N6-biotinyllysine

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain3-456Biotin carboxylation
Domain123-321ATP-grasp
Region482-505Disordered
Compositional bias487-501Basic and acidic residues
Domain533-801Pyruvate carboxyltransferase
Domain1071-1146Lipoyl-binding

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,146
  • Mass (Da)
    124,861
  • Last updated
    2024-01-24 v1
  • Checksum
    A5C196D4F225B7B1
MTEFKKILIANRGEIAIRVMRAANEMGKKTVAVYAEEDKLSLHRFKADEAYLIGEGLSPVGAYLSIPEIIRVARACGADAIHPGYGLLSENPDFVDACDQAGITFIGPKADTMRALGDKASARRVAMEAGVPVIPATEVLGDDFDAIKKEAAAVGYPLMLKASWGGGGRGMRPILGPDELVDKVREGRREAEAAFGNGEGYLEKMIIRARHVEVQILGDKHGAIYHLYERDCTVQRRNQKVVERAPAPYLTDAQRAEVCELGRKICAHVGYECAGTVEFLMDMDNQQFYFIEVNPRVQVEHTVTEQVTGIDIVQAQILIAEGKTLAEATGKPAQSDIHLTGHALQCRVTTEDPQNNFIPDYGRLTAYRSATGNGIRLDGGTAYAGGVITRYYDSLLVKVTATAQTPKAAIARMDRALREFRIRGVSTNIEFVINLLKHPTFLDDTYTTKFIDTTPDLFQFKKRRDRATKILTYIADITVNGHPETAGRPKPHAEARTPRAPKAHAEPAMGTRNLLEQHGPQAVADWMGKQKKLLLTDTTMRDGHQSLLATRMRSIDMIKVAPAYAANLPQLFSVECWGGATFDVAYRFLQECPWQRLRDLRALMPNVMTQMLLRASNGVGYTNYPDNVVQAFVKQAALTGVDVFRVFDSLNWVENMRVAMDAVIEANKVCEGTVCYTGDMLDPDRAKYDLKYYVDTAKQLKAAGAHVLGLKDMAGLLKPAAAKQLIKTLKQEVGLPIHFHTHDTSGAAAATILAAADAGVDCVDAAMDAFSGGTSQPCLGSIVEALRHTDRDTGLDMAAIRSISNYWEAVRGQYAAFESGIPAPASEVYLHEMPGGQFTNLKAQARSLGLEERWHEVAQTYADVNQMFGDIVKVTPSSKVVGDMALMMVAQGLTRAQVEDPKVDVAFPDSVVDMLKGNLGQPHGGWPEAISKKVLKGETASTARPGESLPPVDLEATRAKLSEELGGFKIDDEDLNGYLMYPKVFLDYMGRHKAYGPVRTLPTRTFFYGMAPGEEISAEIDAGKKLEIRLQAVAETTDDGDVKVFFELNGQPRVIRVPNRAIKAKTAAKPKAVEGNAGHIGAPMPGSIASVGVVVGQKVSAGDLLLTIEAMKMETGIHADRAAVVKALHVQPGSQIDAKDLLVELE

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias487-501Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BSPP01000007
EMBL· GenBank· DDBJ
GLS86929.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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