A0AA37TPL6 · A0AA37TPL6_9RHOB
- ProteinBifunctional protein FolD
- GenefolD_1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids296 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
Catalytic activity
- (6R)-5,10-methenyltetrahydrofolate + H2O = (6R)-10-formyltetrahydrofolate + H+
Pathway
One-carbon metabolism; tetrahydrofolate interconversion.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | methenyltetrahydrofolate cyclohydrolase activity | |
Molecular Function | methylenetetrahydrofolate dehydrogenase (NADP+) activity | |
Biological Process | L-histidine biosynthetic process | |
Biological Process | methionine biosynthetic process | |
Biological Process | purine nucleotide biosynthetic process | |
Biological Process | tetrahydrofolate interconversion |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameBifunctional protein FolD
Including 2 domains:
- Recommended nameMethylenetetrahydrofolate dehydrogenase
- EC number
- Recommended nameMethenyltetrahydrofolate cyclohydrolase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Rhodobacterales > Paracoccaceae > Cypionkella
Accessions
- Primary accessionA0AA37TPL6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 6-121 | Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic | ||||
Sequence: IDGKVFAATVRAQVQAHVAKLKADHGIQPGLAVVLVGEDPASQVYVRNKHASTIEVGMASFEHRLPEDTSEADLLALVNSLNGDPKVHAILVQLPLPAHLNSELIINTIDPAKDVD | ||||||
Domain | 125-284 | Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding | ||||
Sequence: ISNVGLLGTGQKSMVPCTPLGCLMMLRDHHGSLAGLNAVVVGRSNIVGKPMAQLLLGDSCTVTIAHSRTKDLAAVCRGADILVAAVGRPEMITGDYVKPGATVIDVGINRIERDGKNKLVGDVHYESAAKVVGAITPVPGGVGPMTIACLLANALTACCR |
Sequence similarities
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length296
- Mass (Da)30,729
- Last updated2024-01-24 v1
- ChecksumC11C8C595723B895
Keywords
- Technical term