A0AA37R8E3 · A0AA37R8E3_PSEPU
- ProteinLipid A deacylase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids172 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety.
Catalytic activity
- a 3-(acyloxy)acyl derivative of bacterial toxin + H2O = 3-hydroxyacyl derivative of bacterial toxin + a fatty acid + H+
Features
Showing features for active site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 148 | Charge relay system | ||||
Sequence: H | ||||||
Active site | 150 | Charge relay system | ||||
Sequence: S | ||||||
Site | 151 | Critical for activity | ||||
Sequence: N | ||||||
Active site | 162 | Charge relay system | ||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cell outer membrane | |
Molecular Function | hydrolase activity |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameLipid A deacylase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas
Accessions
- Primary accessionA0AA37R8E3
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell outer membrane ; Multi-pass membrane protein
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-23 | |||||
Sequence: MKKLLGLVATAAFTLGQVLAAQA | ||||||
Chain | PRO_5041348360 | 24-172 | Lipid A deacylase | |||
Sequence: ADVSFSVGQTGDSTMVYRLGLQSNWDTSWWQTRVGRLTGYWDGAYTYWDGDKTASNHSLSFAPVFVYEFAGESVKPYIEAGIGVAAFSSTELESNELGSAFQFEDRIGFGLRFAGGHEIGVRAIHYSNAGIKEPNDGVESYSLHYRMAL |
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length172
- Mass (Da)18,757
- Last updated2024-01-24 v1
- ChecksumEDFB2EB25752A9FA