A0AA37NKC4 · A0AA37NKC4_9BACT

  • Protein
    Carbamoyl phosphate synthase small chain
  • Gene
    pyrAA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Small subunit of the glutamine-dependent carbamoyl phosphate synthetase (CPSase). CPSase catalyzes the formation of carbamoyl phosphate from the ammonia moiety of glutamine, carbonate, and phosphate donated by ATP, constituting the first step of 2 biosynthetic pathways, one leading to arginine and/or urea and the other to pyrimidine nucleotides. The small subunit (glutamine amidotransferase) binds and cleaves glutamine to supply the large subunit with the substrate ammonia.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site39L-glutamine (UniProtKB | ChEBI)
Binding site215L-glutamine (UniProtKB | ChEBI)
Binding site217L-glutamine (UniProtKB | ChEBI)
Active site242Nucleophile
Binding site243L-glutamine (UniProtKB | ChEBI)
Binding site246L-glutamine (UniProtKB | ChEBI)
Binding site284L-glutamine (UniProtKB | ChEBI)
Binding site287L-glutamine (UniProtKB | ChEBI)
Active site327
Active site329

GO annotations

AspectTerm
Cellular Componentcarbamoyl-phosphate synthase complex
Molecular FunctionATP binding
Molecular Functioncarbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Processarginine biosynthetic process
Biological Processglutamine metabolic process
Biological Processpyrimidine nucleotide biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Carbamoyl phosphate synthase small chain
  • EC number
  • Alternative names
    • Carbamoyl phosphate synthetase glutamine chain

Gene names

    • Name
      pyrAA
    • Synonyms
      carA
    • ORF names
      CE91St16_05740

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • CE91-St16
  • Taxonomic lineage
    Bacteria > Bacteroidota > Bacteroidia > Bacteroidales > Rikenellaceae > Alistipes

Accessions

  • Primary accession
    A0AA37NKC4

Proteomes

Subcellular Location

Interaction

Subunit

Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. Tetramer of heterodimers (alpha,beta)4.

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain1-125Carbamoyl-phosphate synthase small subunit N-terminal
Region1-166CPSase

Sequence similarities

Belongs to the CarA family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    354
  • Mass (Da)
    39,581
  • Last updated
    2024-01-24 v1
  • Checksum
    3CF738E81C1BB6F2
MENGREFYGYGFGADREVINEIVFNTSMVGYQEIMSDPSYTDQMVVMTYPLIGNYGMADEDYETKTPTIGGMIVREYNDSPSNFRYTKTLNEVFEEHDIPAIWGVDTRTLTRIIRNEGTQKVIITGADTPLEEALRKVREYALPHDMVSRVSCKKRWMSRVPNHKYDVVAVDCGIKYNIIRQLNRVGCNVTVVPFDSTLEEIMAFRPDGVVLSNGPGNPQDVTPVIELVRQLRGKLPIFGICMGHQLISLAYGAKTVKMKFGHRGGNHPVKNLSTGKIEITSQNHSYAVDVDSLAGTGLELTHVNLLDGTAEGVECVGDAVFSMQYHPESASGPQDSGYLFRKFTKIMEERKNA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BQOL01000001
EMBL· GenBank· DDBJ
GKI17666.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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