A0AA37N4T7 · A0AA37N4T7_9FIRM

Function

function

Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functioncarboxypeptidase activity
Molecular Functionpenicillin binding
Molecular Functionpeptidoglycan glycosyltransferase activity
Biological Processpeptidoglycan biosynthetic process
Biological Processproteolysis
Biological Processresponse to antibiotic

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Penicillin-binding protein 1A
  • EC number

Gene names

    • ORF names
      CE91St55_48690

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • CE91-St55
  • Taxonomic lineage
    Bacteria > Bacillota > Clostridia > Lachnospirales > Lachnospiraceae > Hungatella

Accessions

  • Primary accession
    A0AA37N4T7

Proteomes

Subcellular Location

Cell membrane
; Single-pass type II membrane protein
Membrane
; Single-pass type II membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane21-42Helical

Keywords

  • Cellular component

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain81-256Glycosyl transferase family 51
Domain380-649Penicillin-binding protein transpeptidase
Region690-730Disordered
Compositional bias698-718Basic and acidic residues
Region796-849Disordered

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    849
  • Mass (Da)
    93,823
  • Last updated
    2024-01-24 v1
  • Checksum
    AF3FB633712D9E65
MKKKRRKRKSAWAVFFKPIKVIFSIFLILMILGLGAGGIVYLKFGDEISACKERADQIVAQSKREDFSQPSDTRIYDSSGQVIGIINTGHYEYVPITEISENLQNAYIAQEDKRFYQHHGVDIIGLARAGVALVKNKGEITQGGSTITQQVIKNTYLTQEKSFTRKITEIFAAPQMEEKYSKADILEFYCNTNFYANRCYGVAKASLFYFDKEAKDLTVWEAATLAGISNNPSRYNPVAHPEAALEKRNKIIDNMQKNGMLTEEECETAKAQPLTVAKVTEEGTKETYQSSYAVHCAAQELMKNDGFEFEYTFADEAAYNDYKERYQEAYQEKSDLIRNGGFEIHTSLDSTLQTQLQAGIDETLAKFTDVSENGKYALQGAAVCIDNRTGYVVAISGGRGTDDEYNRGFLSRRQPGSTIKPLIDYAPAFETGYYYPSRMVNDHLFDKGPKNSGNKYYGEVSVREALNRSLNTVAWQVLADIGVDYGMSYLDKMHFVGLSYLDNWNTSMSIGGFTEGARVVDMARGYSVLANGGMYSNNTCITGIDSQYEGDLYQENQPEERIFTEDTAYMVTDVLKGTLNQPYGTGYGLGLPIPAAGKTGTTNSSKDTWFCGYTKYYTTAVWVGYDTPKAMPGVYGKTYAGKIWYDFMKQCNEGLPAEDWVMPSTVAYYNVDSRGEKTSQETGKQDLFSSVAEQNARSNSKKWDEEQKMKEENARAAAEQASRDAAAQGQEQAAAGLTALIGELNALAYQDDTTQEKISQGRTMLEMLDGTEQYEALKQQFDEAAARAGSLPYEEQTVPPSQEIGPGITHEARPGEAPSASQDITSGQAPGVQPGAAPGGIEAVGPGGL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias698-718Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BQNJ01000002
EMBL· GenBank· DDBJ
GKH02888.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp