A0AA37N4T7 · A0AA37N4T7_9FIRM
- ProteinPenicillin-binding protein 1A
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids849 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
function
Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
Catalytic activity
- [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H+
[GlcNAc-(1→4)-Mur2Ac(oyl-L-Ala-γ-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate RHEA-COMP:9602 + CHEBI:60033 = [GlcNAc-(1→4)-Mur2Ac(oyl-L-Ala-γ-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate RHEA-COMP:9603 + CHEBI:58405 + CHEBI:15378
Pathway
Cell wall biogenesis; peptidoglycan biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | carboxypeptidase activity | |
Molecular Function | penicillin binding | |
Molecular Function | peptidoglycan glycosyltransferase activity | |
Biological Process | peptidoglycan biosynthetic process | |
Biological Process | proteolysis | |
Biological Process | response to antibiotic |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePenicillin-binding protein 1A
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacillota > Clostridia > Lachnospirales > Lachnospiraceae > Hungatella
Accessions
- Primary accessionA0AA37N4T7
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type II membrane protein
Membrane ; Single-pass type II membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 21-42 | Helical | ||||
Sequence: VIFSIFLILMILGLGAGGIVYL |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 81-256 | Glycosyl transferase family 51 | ||||
Sequence: QVIGIINTGHYEYVPITEISENLQNAYIAQEDKRFYQHHGVDIIGLARAGVALVKNKGEITQGGSTITQQVIKNTYLTQEKSFTRKITEIFAAPQMEEKYSKADILEFYCNTNFYANRCYGVAKASLFYFDKEAKDLTVWEAATLAGISNNPSRYNPVAHPEAALEKRNKIIDNMQ | ||||||
Domain | 380-649 | Penicillin-binding protein transpeptidase | ||||
Sequence: GAAVCIDNRTGYVVAISGGRGTDDEYNRGFLSRRQPGSTIKPLIDYAPAFETGYYYPSRMVNDHLFDKGPKNSGNKYYGEVSVREALNRSLNTVAWQVLADIGVDYGMSYLDKMHFVGLSYLDNWNTSMSIGGFTEGARVVDMARGYSVLANGGMYSNNTCITGIDSQYEGDLYQENQPEERIFTEDTAYMVTDVLKGTLNQPYGTGYGLGLPIPAAGKTGTTNSSKDTWFCGYTKYYTTAVWVGYDTPKAMPGVYGKTYAGKIWYDFMK | ||||||
Region | 690-730 | Disordered | ||||
Sequence: SVAEQNARSNSKKWDEEQKMKEENARAAAEQASRDAAAQGQ | ||||||
Compositional bias | 698-718 | Basic and acidic residues | ||||
Sequence: SNSKKWDEEQKMKEENARAAA | ||||||
Region | 796-849 | Disordered | ||||
Sequence: QTVPPSQEIGPGITHEARPGEAPSASQDITSGQAPGVQPGAAPGGIEAVGPGGL |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length849
- Mass (Da)93,823
- Last updated2024-01-24 v1
- ChecksumAF3FB633712D9E65
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 698-718 | Basic and acidic residues | ||||
Sequence: SNSKKWDEEQKMKEENARAAA |