A0AA37N0L8 · A0AA37N0L8_9BACT

  • Protein
    Phosphoribosylformylglycinamidine synthase
  • Gene
    purL
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide: step 1/2.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site260-271ATP (UniProtKB | ChEBI)
Binding site624Mg2+ (UniProtKB | ChEBI)
Binding site663Mg2+ (UniProtKB | ChEBI)
Binding site667Mg2+ (UniProtKB | ChEBI)
Binding site826Mg2+ (UniProtKB | ChEBI)
Binding site828ATP (UniProtKB | ChEBI)
Active site1075Nucleophile
Active site1188
Active site1190

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionphosphoribosylformylglycinamidine synthase activity
Biological Process'de novo' IMP biosynthetic process
Biological Processglutamine metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoribosylformylglycinamidine synthase
  • EC number
  • Short names
    FGAM synthase
    ; FGAMS
  • Alternative names
    • Formylglycinamide ribonucleotide amidotransferase
      (FGAR amidotransferase
      ; FGAR-AT
      )

Gene names

    • Name
      purL
    • ORF names
      CE91St2_25500

Organism names

  • Taxonomic identifier
  • Strain
    • CE91-St2
  • Taxonomic lineage
    Bacteria > Bacteroidota > Bacteroidia > Bacteroidales > Tannerellaceae > Parabacteroides

Accessions

  • Primary accession
    A0AA37N0L8

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain13-80Phosphoribosylformylglycinamidine synthase N-terminal
Domain122-171Phosphoribosylformylglycinamidine synthase linker
Domain380-531PurM-like C-terminal
Domain594-747FGAR-AT PurM-N-like
Domain780-903PurM-like C-terminal

Sequence similarities

In the N-terminal section; belongs to the FGAMS family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,229
  • Mass (Da)
    135,648
  • Last updated
    2024-01-24 v1
  • Checksum
    8F07A764E9C1F17E
MILFFQSPTKTVLAVEAAHAFSPEDVQKLVWLFSEAAPLQSETLDGWYVGPRREMITPWSTNAVEITQNMGLSGISRIEEYFPVSSGEADHDPMLQRIYNGLNQDIFTISKQPDPIVYIEDIAAYNKKEGLALSDEEVSYLNEVSQKLERKLTDSEVYGFAQVNSEHCRHKIFGGTFVIDGEEKESSLFNLIKKTSAENPNKLVSAYKDNVAFNEGPMIEQFAPASGDKPDFYEVKEIKSVISLKAETHNFPTTVEPFNGAATGSGGEIRDRLGGGKASLPIAGTAVYMTAYPRTEGAREWEKVLDPRPWLYQTPEQILIKASNGASDFGNKFGQPLICGSVLTFEHEENNKKYAYDKVIMLAGGVGYANMRDALKGDPQPGEKVVLLGGDNYRIGMGGGAVSSVNTGQYTSGIELNAVQRANPEMQKRVSNVIRAIAESDNNPVVSIHDHGAGGHLNCLSELVEATGGHIDMSQLPVGDPTLSAKEIVGNESQERMGLLMKEEDVACVRRIADRERSPMYVVGETTNDMKFVFEQADGVKPIDIKLEYMFGKPPRTIMKDHTVEETYAPVVYKESELHHYLENVLQLEAVACKDWLTNKVDRSVTGKIARQQCQGELQLPLSDLGAVALDYRGKAGIATSIGHAPQVAMIDPAAGSVMAIAESLTNIVFAPLADKLTGVSLSANWMWPCRNEGEDARLYTAVQAASDFACELGINIPTGKDSLSMTQKYGDDKVIAPGTVIISAGAEVSDVRKIVSPVLAHEKNSYIYYIDFSFDTMKLGGSAFAQTLNKLGDEVPTVKDSEYFADAFNAVQDAIEKGLILAGHDISAGGMITTLLEMCFANVEGGLEVNLDKLSETDIVKILFAENPGILVQVKDKKAFEKLMEEAGVGCAVIAKPTDERHILVEKEGVQYHFGIDYMRDVWYESSYKLDIKQSGSVCAGNRFENYKMQPLEFKYNKNFTGKLADYGLTPDRKGKSGIRAAVIREKGCQCERETSYALYLAGFDVKDVHMTDLASGRETLEDVNMIVFCGGFSNSDVLGSAKGWAGGFLYNEKAKKALDNFYARPDTLSLGICNGCQLMAELGVVYPEHEKKHKMLHNDSHKLESNFISVEIPKNHSVMFGPMSGQKLGIWITHGEGKFWFPYEEKEYHIALKYNYEGYPANPNGSPWSVAGVCSHDGRHMAMMPHLERALFPWQCGYYPADRKGDEVTPWIEGFVNARKWIEENKK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BQND01000001
EMBL· GenBank· DDBJ
GKG79358.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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