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A0AA36UIT7 · A0AA36UIT7_9NEIS

  • Protein
    2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
  • Gene
    ispD
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6.

Features

Showing features for site.

TypeIDPosition(s)Description
Site17Transition state stabilizer
Site24Transition state stabilizer
Site157Positions MEP for the nucleophilic attack
Site211Positions MEP for the nucleophilic attack

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
  • EC number
  • Alternative names
    • 4-diphosphocytidyl-2C-methyl-D-erythritol synthase
    • MEP cytidylyltransferase
      (MCT
      )

Gene names

    • Name
      ispD
    • ORF names
      HMPREF9418_1651

Organism names

  • Taxonomic identifier
  • Strain
    • ATCC 33926
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Neisseriales > Neisseriaceae > Neisseria

Accessions

  • Primary accession
    A0AA36UIT7

Proteomes

Family & Domains

Sequence similarities

Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    228
  • Mass (Da)
    24,628
  • Last updated
    2024-01-24 v1
  • MD5 Checksum
    10B611539B571467F38C018C5C5B16C2
MTRRHIALIPAAGVGTRFGARKPKQYVEINGKTVLQHTIDIFENHPAIDLIAVIVSPEDQTFQTTPSSKTRVFRVGGASRAETVRNGVSALLAQGLAAEQDNILVHDAARCCLPPEALTRLIEEAGGKEQGGILAIPVADTLKRVDGKNHIGETVSRTGLWQAQTPQLFQTALLHRALSAEDLSGITDEASAVEKLGVQPLLVQGDTRNLKLTLPQDEFIVRLLLQVV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AFQE01000079
EMBL· GenBank· DDBJ
EGQ76780.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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