A0AA36CXZ3 · A0AA36CXZ3_9BILA
- ProteinDiacylglycerol O-acyltransferase 1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids731 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- (9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H+ = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2OThis reaction proceeds in the forward direction.
- (9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoAThis reaction proceeds in the forward direction.
- (9Z)-octadecenoyl-CoA + 1,3-di-(9Z-octadecenoyl)-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoAThis reaction proceeds in the forward direction.
- (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-glycerol + CoAThis reaction proceeds in the forward direction.
- (9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-glycerol = 1-O-(9Z-octadecyl)-3-(9Z-octadecenoyl)-glycerol + CoAThis reaction proceeds in the forward direction.
- (9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecyl)-3-(9Z-octadecenoyl)-glycerol = 1-O-(9Z-octadecenyl)-2,3-di-(9Z-octadecenoyl)glycerol + CoAThis reaction proceeds in the forward direction.
- (9Z)-octadecenoyl-CoA + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-3-(9Z)-octadecenoyl-sn-glycerol + CoAThis reaction proceeds in the forward direction.
- (9Z)-octadecenoyl-CoA + 2,3-di-(9Z)-octadecenoyl-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoAThis reaction proceeds in the forward direction.
- (9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CoAThis reaction proceeds in the forward direction.
- 1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoAThis reaction proceeds in the forward direction.
- 13-cis-retinol + hexadecanoyl-CoA = 13-cis-retinyl hexadecanoate + CoAThis reaction proceeds in the forward direction.
- 2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoAThis reaction proceeds in the forward direction.
- all-trans-retinol + hexadecanoyl-CoA = all-trans-retinyl hexadecanoate + CoAThis reaction proceeds in the forward direction.
- hexadecan-1-ol + hexadecanoyl-CoA = CoA + hexadecanyl hexadecanoateThis reaction proceeds in the forward direction.
- hexadecane-1,2-diol + 2 hexadecanoyl-CoA = 1,2-O,O-dihexadecanoyl-1,2-hexadecanediol + 2 CoAThis reaction proceeds in the forward direction.
- hexadecane-1,2-diol + hexadecanoyl-CoA = 2-hydroxyhexadecyl hexadecanoate + CoAThis reaction proceeds in the forward direction.
Pathway
Lipid metabolism; glycerolipid metabolism.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 418 | |||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | diacylglycerol O-acyltransferase activity | |
Biological Process | triglyceride biosynthetic process |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDiacylglycerol O-acyltransferase 1
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Mesorhabditinae > Mesorhabditis
Accessions
- Primary accessionA0AA36CXZ3
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 93-118 | Helical | ||||
Sequence: FFNLAILLLVVSNGRVALENVIKYGI | ||||||
Transmembrane | 138-157 | Helical | ||||
Sequence: WPNLFMILFSNITIVIVLVM | ||||||
Transmembrane | 169-193 | Helical | ||||
Sequence: HFAAAFYTLLIGAHVTVPATITLYL | ||||||
Transmembrane | 199-220 | Helical | ||||
Sequence: YATGCLGLIVIESLKLVSYVHV | ||||||
Transmembrane | 285-304 | Helical | ||||
Sequence: TCELTFLSFLIVALVQQWVV | ||||||
Transmembrane | 334-358 | Helical | ||||
Sequence: ILIWLIGFYTMFHSALNLLAELLCF | ||||||
Transmembrane | 404-426 | Helical | ||||
Sequence: FLASLAVFFVSAAFHEYLVSVPL | ||||||
Transmembrane | 432-451 | Helical | ||||
Sequence: WAYYGMMAQVPLSFVTDYVV | ||||||
Transmembrane | 460-483 | Helical | ||||
Sequence: IVWLSLILGQPMAILMYVHDWYLI |
Keywords
- Cellular component
Interaction
Subunit
Homodimer or homotetramer; both forms have similar enzymatic activities.
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 12-54 | Disordered | ||||
Sequence: SLSHGLSGGDDDKNGVRRRRNSGQSQISGNSNSSNNDSPSRKP | ||||||
Compositional bias | 31-53 | Polar residues | ||||
Sequence: RNSGQSQISGNSNSSNNDSPSRK | ||||||
Region | 621-731 | Disordered | ||||
Sequence: ALPSDSLESESSPSPSKPLRRGQRQRHGGAEDWSDDGDAAGEDEKPSEKPLMASKHVSKAKPGVSSVEAPPEKPRAVKNFGKVVVKTASKATTKRTKKTRAGADDWSDDDE | ||||||
Compositional bias | 625-639 | Polar residues | ||||
Sequence: DSLESESSPSPSKPL | ||||||
Compositional bias | 644-675 | Basic and acidic residues | ||||
Sequence: RQRHGGAEDWSDDGDAAGEDEKPSEKPLMASK |
Sequence similarities
Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length731
- Mass (Da)82,699
- Last updated2024-01-24 v1
- ChecksumCDFAFF2E3A892A9A
Features
Showing features for compositional bias, non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 31-53 | Polar residues | ||||
Sequence: RNSGQSQISGNSNSSNNDSPSRK | ||||||
Compositional bias | 625-639 | Polar residues | ||||
Sequence: DSLESESSPSPSKPL | ||||||
Compositional bias | 644-675 | Basic and acidic residues | ||||
Sequence: RQRHGGAEDWSDDGDAAGEDEKPSEKPLMASK | ||||||
Non-terminal residue | 731 | |||||
Sequence: E |
Keywords
- Technical term