A0AA36CX84 · A0AA36CX84_9BILA
- ProteinTranscription initiation factor IIF subunit alpha
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids339 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Cellular Component | nucleus | |
Molecular Function | DNA binding | |
Molecular Function | metal ion binding | |
Biological Process | mitochondrial cytochrome c oxidase assembly | |
Biological Process | positive regulation of transcription elongation by RNA polymerase II | |
Biological Process | transcription initiation at RNA polymerase II promoter |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameTranscription initiation factor IIF subunit alpha
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Mesorhabditinae > Mesorhabditis
Accessions
- Primary accessionA0AA36CX84
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Disulfide bond | 25↔29 | Redox-active | ||||
Sequence: CPDIC |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 45-270 | Disordered | ||||
Sequence: ADPTQKQPKIKDNFSDTDASDEEDEDGERSRSKGTKNKKKKGAETEKKDKRVRVKESDDVAKYESEDGEEDGQEVDYMSDSGSDSDRDNVPMEEKIEKAMVGVDDEDGLRKLGSSEDEREEDEEEQEAEKNKNNDFRSKAQADKDDSSDSDLDEDGEMTKSILLLPKKNLAASTSSSGKPVDHATAKKRAIEDAVAGVEAKRTKLEGDDGTPRPAGASRDQSDGLN | ||||||
Compositional bias | 70-106 | Basic and acidic residues | ||||
Sequence: DGERSRSKGTKNKKKKGAETEKKDKRVRVKESDDVAK | ||||||
Compositional bias | 107-121 | Acidic residues | ||||
Sequence: YESEDGEEDGQEVDY | ||||||
Compositional bias | 124-161 | Basic and acidic residues | ||||
Sequence: DSGSDSDRDNVPMEEKIEKAMVGVDDEDGLRKLGSSED | ||||||
Compositional bias | 173-190 | Basic and acidic residues | ||||
Sequence: EKNKNNDFRSKAQADKDD | ||||||
Compositional bias | 226-253 | Basic and acidic residues | ||||
Sequence: DHATAKKRAIEDAVAGVEAKRTKLEGDD |
Sequence similarities
Belongs to the SCO1/2 family.
Belongs to the TFIIF alpha subunit family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length339
- Mass (Da)37,965
- Last updated2024-01-24 v1
- Checksum4F6BCD628FC170C0
Features
Showing features for non-terminal residue, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: M | ||||||
Compositional bias | 70-106 | Basic and acidic residues | ||||
Sequence: DGERSRSKGTKNKKKKGAETEKKDKRVRVKESDDVAK | ||||||
Compositional bias | 107-121 | Acidic residues | ||||
Sequence: YESEDGEEDGQEVDY | ||||||
Compositional bias | 124-161 | Basic and acidic residues | ||||
Sequence: DSGSDSDRDNVPMEEKIEKAMVGVDDEDGLRKLGSSED | ||||||
Compositional bias | 173-190 | Basic and acidic residues | ||||
Sequence: EKNKNNDFRSKAQADKDD | ||||||
Compositional bias | 226-253 | Basic and acidic residues | ||||
Sequence: DHATAKKRAIEDAVAGVEAKRTKLEGDD |
Keywords
- Technical term