A0AA35TJC9 · A0AA35TJC9_GEOBA
- ProteinN-alpha-acetyltransferase 20
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids521 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration.
Catalytic activity
- N-terminal L-methionyl-L-asparaginyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-asparaginyl-[protein] + CoA + H+
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Cellular Component | NatB complex | |
Molecular Function | ATP binding | |
Molecular Function | peptide alpha-N-acetyltransferase activity | |
Molecular Function | protein kinase activity | |
Biological Process | N-terminal peptidyl-methionine acetylation | |
Biological Process | protein phosphorylation |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameN-alpha-acetyltransferase 20
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Porifera > Demospongiae > Heteroscleromorpha > Tetractinellida > Astrophorina > Geodiidae > Geodia
Accessions
- Primary accessionA0AA35TJC9
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 219-243 | Helical | |||
Keywords
- Cellular component
Interaction
Subunit
Component of the N-terminal acetyltransferase B (NatB) complex which is composed of NAA20 and NAA25.
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 2-155 | N-acetyltransferase | |||
Compositional bias | 289-323 | Polar residues | |||
Region | 289-346 | Disordered | |||
Compositional bias | 324-345 | Basic and acidic residues | |||
Domain | 358-521 | Protein kinase | |||
Compositional bias | 383-410 | Basic and acidic residues | |||
Region | 383-421 | Disordered | |||
Sequence similarities
Belongs to the acetyltransferase family. ARD1 subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length521
- Mass (Da)59,061
- Last updated2024-01-24 v1
- Checksum0BAACF3C81E678E9
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 289-323 | Polar residues | |||
Compositional bias | 324-345 | Basic and acidic residues | |||
Compositional bias | 383-410 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CASHTH010003786 EMBL· GenBank· DDBJ | CAI8049380.1 EMBL· GenBank· DDBJ | Genomic DNA |