A0AA35RIJ5 · A0AA35RIJ5_GEOBA
- ProteinrRNA adenine N(6)-methyltransferase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids739 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 27 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 29 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 54 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 75 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 100 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 121 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | plasma membrane | |
Molecular Function | 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity | |
Molecular Function | ATP binding | |
Molecular Function | phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity | |
Molecular Function | RNA binding | |
Molecular Function | rRNA (adenine-N6,N6-)-dimethyltransferase activity | |
Biological Process | lipoprotein biosynthetic process | |
Biological Process | terpenoid biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namerRNA adenine N(6)-methyltransferase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Porifera > Demospongiae > Heteroscleromorpha > Tetractinellida > Astrophorina > Geodiidae > Geodia
Accessions
- Primary accessionA0AA35RIJ5
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 523-548 | Helical | |||
Transmembrane | 668-688 | Helical | |||
Transmembrane | 700-717 | Helical | |||
Keywords
- Cellular component
Interaction
Subunit
Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-24 | Disordered | |||
Domain | 34-204 | Ribosomal RNA adenine methylase transferase N-terminal | |||
Sequence similarities
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length739
- Mass (Da)79,405
- Last updated2024-01-24 v1
- ChecksumFA13D03C98C10D6C
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CASHTH010001096 EMBL· GenBank· DDBJ | CAI8011343.1 EMBL· GenBank· DDBJ | Genomic DNA |