A0AA35RIJ5 · A0AA35RIJ5_GEOBA

Function

function

Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Features

Showing features for binding site.

1739100200300400500600700
TypeIDPosition(s)Description
Binding site27S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site29S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site54S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site75S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site100S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site121S-adenosyl-L-methionine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentplasma membrane
Molecular Function4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity
Molecular FunctionATP binding
Molecular Functionphosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity
Molecular FunctionRNA binding
Molecular FunctionrRNA (adenine-N6,N6-)-dimethyltransferase activity
Biological Processlipoprotein biosynthetic process
Biological Processterpenoid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    rRNA adenine N(6)-methyltransferase
  • EC number

Gene names

    • ORF names
      GBAR_LOCUS7337

Organism names

Accessions

  • Primary accession
    A0AA35RIJ5

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane523-548Helical
Transmembrane668-688Helical
Transmembrane700-717Helical

Keywords

Interaction

Subunit

Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region1-24Disordered
Domain34-204Ribosomal RNA adenine methylase transferase N-terminal

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    739
  • Mass (Da)
    79,405
  • Last updated
    2024-01-24 v1
  • Checksum
    FA13D03C98C10D6C
MTLPDQTPGALPATSSRRRPRKSLGQHFLTDPRIAQRIVAAAQPSPGDTILEIGPGSGTLTRRLIASGSNVIAVEIDPHLAAVLPERMDNPPNLKVVQGDARTIDIPALLEGRSTYKLVANLPYYAAAPILRRFLESQVPPTSLIVMVQREVADAMCAAPGQMTLMSVATQLYAVPSVVAQVPPRSFRPPPKVSSTVIKLVMKETQPDPLNGIEEFFALVRSGFSAPRKQLRNSLMQGSGSPAEFVSAVLTDAGIDGQRRPATLSIPEWLTLDTHWPAGVPRHRSQHNSGEVQAFAKVNLTLEIIGRRSDGYHDVATILQSIDLADTLTIKPAGSLTVECDDPDLDGQRNLIWRAAVALADHAGVRPNAHIHLTKQIPVAAGLGGGSSDAASALRGLNDLWQLQISREELAKVAAGIGSDVPFCIDGGTALATGRGDQLIPLPPLPPHDVLLVVPRETLESKTPTLFAALEPGDFSDGSCTHRISSTITDTLITSGQWRNAFERAALEIFPGLSDPIPVSVLYFWQGGIAIFGAYLGGFVGGASYILLRNASWLNRLCDRPTCRWTGLHLPFTQLPSVPHLADITAPALLIALAIGRLGDVINGEHCATFSGLPWAVVYSDPDSLYNRCVHGGAAATHPAVAYELIFCLALAGILWLMKDRLQPHGMLFALFFAGYSIGRFFISFLRVESNTYLFGFNEAQLVALAIMLVTVPLLVYKARLVRPTPSGSGPRSGRRRAS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CASHTH010001096
EMBL· GenBank· DDBJ
CAI8011343.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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